{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:59:42Z","timestamp":1740171582884,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,12]],"date-time":"2014-02-12T00:00:00Z","timestamp":1392163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI12\/01759"],"award-info":[{"award-number":["PI12\/01759"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Droxidopa improves hemodynamic and renal alterations of cirrhotic rats without changing portal pressure. We aimed to evaluate the effects of a combined treatment with droxidopa and non\u2010selective beta\u2010blockers or statins in order to decrease portal pressure, while maintaining droxidopa beneficial effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acute studies combining droxidopa with carvedilol, propranolol or atorvastatin in four\u2010week bile\u2010duct ligated (<jats:styled-content style=\"fixed-case\">BDL<\/jats:styled-content>) rats and a chronic study combining propranolol and droxidopa for 5\u00a0days in <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010cirrhotic rats were performed. Hemodynamic values were registered and biochemical parameters from blood and urine samples analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bile\u2010duct ligated rats treated with carvedilol\u00a0+\u00a0droxidopa showed no changes in mean arterial pressure (<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>) and portal pressure (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>) compared to vehicles. Atorvastatin\u00a0+\u00a0droxidopa combination also failed to reduce <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>, but maintained the beneficial increase in <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> and superior mesenteric artery resistance (<jats:styled-content style=\"fixed-case\">SMAR<\/jats:styled-content>) and decrease in blood flow (<jats:styled-content style=\"fixed-case\">SMABF<\/jats:styled-content>) caused by droxidopa. In contrast, the acute administration of propranolol\u00a0+\u00a0droxidopa significantly reduced <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> maintaining a mild increase in <jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content> and improving, in an additive way, the decrease in <jats:styled-content style=\"fixed-case\">SMABF<\/jats:styled-content> and increase in <jats:styled-content style=\"fixed-case\">SMAR<\/jats:styled-content> caused by droxidopa. This combination also preserved droxidopa diuretic effect. When chronically administered to <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>l<jats:sub>4<\/jats:sub>\u2010cirrhotic rats, propranolol\u00a0+\u00a0droxidopa caused a decrease in <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>, a significant reduction in <jats:styled-content style=\"fixed-case\">SMABF<\/jats:styled-content> and an increase in <jats:styled-content style=\"fixed-case\">SMAR<\/jats:styled-content>. The combination did not alter liver function and droxidopa diuretic and natriuretic effect, and even improved free water clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Droxidopa could be effective for the renal alterations of cirrhotic patients on propranolol therapy and the combination of both drugs may balance the adverse effects of each treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12472","type":"journal-article","created":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T10:50:48Z","timestamp":1390128648000},"page":"326-334","source":"Crossref","is-referenced-by-count":6,"title":["The renal effects of droxidopa are maintained in propranolol treated cirrhotic rats"],"prefix":"10.1111","volume":"35","author":[{"given":"Sarai","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Liver Diseases Laboratory Liver Unit Department of Internal Medicine Hospital Universitari Vall d'Hebron Institut de Recerca (VHIR) Universitat 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