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No study directly comparing sorafenib and <jats:styled-content style=\"fixed-case\">TARE<\/jats:styled-content> is currently available. This single\u2010centre retrospective study compares the outcomes achieved with sorafenib and <jats:styled-content style=\"fixed-case\">TARE<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients potentially amenable to either therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010four sorafenib (71\u00a0\u00b1\u00a010\u00a0years, male 87%, <jats:styled-content style=\"fixed-case\">BCLC<\/jats:styled-content> B\/C 53%\/47%) and 63 <jats:styled-content style=\"fixed-case\">TARE HCC<\/jats:styled-content> patients (66\u00a0\u00b1\u00a09\u00a0years, male 79%, <jats:styled-content style=\"fixed-case\">BCLC<\/jats:styled-content> B\/C 41%\/59%) were included based on the following criteria: Child\u2013Pugh class A\/B, performance status \u22641, <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> unfit for other effective therapies, no metastases and no previous systemic chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median overall survivals of the two groups were comparable, being 14.4\u00a0months (95% CI: 4.3\u201324.5) in sorafenib and 13.2\u00a0months (95% CI: 6.1\u201320.2) in <jats:styled-content style=\"fixed-case\">TARE<\/jats:styled-content> patients, with 1\u2010, 2\u2010 and 3\u2010year survival rates of 52.1%, 29.3% and 14.7% vs 51.8%, 27.8% and 21.6% respectively. Two <jats:styled-content style=\"fixed-case\">TARE<\/jats:styled-content> patients underwent liver transplantation after successful down\u2010staging. To minimize the impact of confounding factors on survival analysis, propensity model matched 32 patients of each group for median age, tumour gross pathology and the independent prognostic factors (portal vein thrombosis, performance status, Model for End Liver Disease). Even after matching, the median survival did not differ between sorafenib (13.1\u00a0months; 95% CI: 1.2\u201325.9) and <jats:styled-content style=\"fixed-case\">TARE<\/jats:styled-content> patients (11.2\u00a0months; 95% CI: 6.7\u201315.7), with comparable 1\u2010, 2\u2010 and 3\u2010year survival rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cirrhotic patients with intermediate\u2010advanced or not\u2010otherwise\u2010treatable <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>, sorafenib and <jats:styled-content style=\"fixed-case\">TARE<\/jats:styled-content> provide similar survivals. Down\u2010staging allowing liver transplantation only occurred after <jats:styled-content style=\"fixed-case\">TARE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12574","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T07:41:39Z","timestamp":1398152499000},"page":"1036-1047","source":"Crossref","is-referenced-by-count":95,"title":["Yttrium\u201090 radioembolization vs sorafenib for intermediate\u2010locally advanced hepatocellular carcinoma: a cohort study with propensity score analysis"],"prefix":"10.1111","volume":"35","author":[{"given":"Annagiulia","family":"Gramenzi","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum \u2013 University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Golfieri","sequence":"additional","affiliation":[{"name":"Radiology Unit S. 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