{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:11:29Z","timestamp":1790395889908,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hepatitis E virus (\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    ) infection is a global problem that affects 20 million individuals, and cause acute hepatitis in 3.5 million, with approximately 70\u00a0000 deaths worldwide per year. While the acute disease is generally self\u2010limited, however, it may progress to fatal fulminant liver failure in certain individuals. Contaminated water supplies disseminate this virus through the faecal\u2013oral route, and swine is thought to be its zoonotic reservoir. Attempts have been made to develop effective\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    vaccines, and two candidates have undergone successful clinical trials. In this review, we discuss\n                    <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\n                    epidemiology, genotypes, microbiological structure, as well as the most recent advances in vaccination developments.\n                  <\/jats:p>","DOI":"10.1111\/liv.12590","type":"journal-article","created":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T09:47:19Z","timestamp":1400233639000},"page":"311-316","source":"Crossref","is-referenced-by-count":24,"title":["Making the case for the development of a vaccination against hepatitis E virus"],"prefix":"10.1111","volume":"35","author":[{"given":"Samir","family":"Haffar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Al\u2010Mouassat University Hospital Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateh","family":"Bazerbachi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Lake","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Minnesota Minneapolis MN 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