{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:38:35Z","timestamp":1761597515604},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Aim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms (SNP<\/jats:styled-content>s) of the IL<\/jats:styled-content>\u201028B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HB<\/jats:styled-content>sAg persistence. Further, a potential effect on the development of HB<\/jats:styled-content>eAg\u2010negative CHB<\/jats:styled-content> vs. inactive HB<\/jats:styled-content>sAg carrier state was assessed in a genotype D HBV<\/jats:styled-content> cohort. A cohort of chronic HDV<\/jats:styled-content> patients was also used to see if they behave differently compared to chronic HBV<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study was conducted in three main patient cohorts: Group 1 consisted of 482 patients with HB<\/jats:styled-content>sAg persistence. Of them 143 were inactive carriers, 94 had HB<\/jats:styled-content>eAg\u2010positive chronic hepatitis B (CHB<\/jats:styled-content>) and 245 had anti\u2010HB<\/jats:styled-content>e\u2010positive CHB<\/jats:styled-content>. Group 2 represents spontaneously recovered HBV<\/jats:styled-content> patients; they were anti\u2010HB<\/jats:styled-content>s and anti\u2010HB<\/jats:styled-content>c positive. Group 3 consisted of 176 chronic hepatitis delta (CHD<\/jats:styled-content>) patients with antidelta and HDV<\/jats:styled-content>\u2010RNA<\/jats:styled-content> positivity. DNA<\/jats:styled-content> sequencing was performed for genotyping.<\/jats:p><\/jats:sec>Results<\/jats:title>When patients with HB<\/jats:styled-content>sAg persistence were compared with spontaneously recovered patients, a significant difference was observed for rs8105790 (P<\/jats:italic>\u00a0<\u00a00.0001), rs12980275 (P<\/jats:italic>\u00a0<\u00a00.02). Patients who had the CC<\/jats:styled-content>\/TC<\/jats:styled-content> genotype for rs8105790 (P<\/jats:italic>\u00a0<\u00a00.0001) and AA<\/jats:styled-content> genotype for 1188122 (P<\/jats:italic>\u00a0<\u00a00.02) were more likely to be inactive HB<\/jats:styled-content>sAg carriers, when inactive HB<\/jats:styled-content>sAg carriers were compared with HB<\/jats:styled-content>eAg\u2010negative CHB<\/jats:styled-content> patients. Comparison of CHD<\/jats:styled-content> patients vs. recovered HBV<\/jats:styled-content> patients was parallel to that of HBV<\/jats:styled-content> persistence vs. recovered HBV<\/jats:styled-content> with similar significant differences in same SNP<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These results suggest that IL<\/jats:styled-content>\u201028B polymorphisms may contribute to HB<\/jats:styled-content>sAg persistence and the development of the inactive HB<\/jats:styled-content>sAg carrier state.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12595","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T09:50:01Z","timestamp":1400579401000},"page":"846-853","source":"Crossref","is-referenced-by-count":12,"title":["Interleukin\u201028 gene polymorphisms may contribute to HB<\/scp>sAg persistence and the development of HB<\/scp>eAg\u2010negative chronic hepatitis B"],"prefix":"10.1111","volume":"35","author":[{"given":"Senem C.","family":"Karatayl\u0131","sequence":"first","affiliation":[{"name":"Institute of Hepatology Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mithat","family":"Bozday\u0131","sequence":"additional","affiliation":[{"name":"Institute of Hepatology Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersin","family":"Karatayl\u0131","sequence":"additional","affiliation":[{"name":"Institute of Hepatology Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tu\u011fba","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Institute of Hepatology Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas A.","family":"Husseini","sequence":"additional","affiliation":[{"name":"Institute of Hepatology Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Biometry Genetics Department Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhip","family":"\u00d6zkan","sequence":"additional","affiliation":[{"name":"Biometry Genetics Department Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Kalayl\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Statistics Middle East Technical University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendal","family":"Yal\u00e7\u0131n","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Medicine Dicle University Diyarbakir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kubilay","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Medicine Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"\u0130dilman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Medicine Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cihan","family":"Yurdayd\u0131n","sequence":"additional","affiliation":[{"name":"Institute of Hepatology Ankara University Ankara Turkey"},{"name":"Department of Gastroenterology School of Medicine Ankara University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08463"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08309"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.449"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.447"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni873"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.348"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028798"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2011.0027"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr301"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.638"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.6.3851-3854.2005"},{"key":"e_1_2_6_14_1","first-page":"LB","article-title":"Association between treatment outcome and rs12979860 polymorphism in HBeAg positive and negative chronic hepatitis B patients treated with Peginterferon alfa\u20102a (Pegasys) and Adefovir (Hepsera); 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