{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:07:05Z","timestamp":1791184025216,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Health Department"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Hepatitis E virus (<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>) infection is a known cause of acute\u2010on\u2010chronic liver failure in developing countries, but its implication in Western countries remains unknown. <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> burden in the setting of severe acute alcoholic hepatitis (<jats:styled-content style=\"fixed-case\">AAH<\/jats:styled-content>) was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients admitted for severe <jats:styled-content style=\"fixed-case\">AAH<\/jats:styled-content> from 2007 to 2013, with available sera and histologically proven <jats:styled-content style=\"fixed-case\">AAH<\/jats:styled-content>, were included and managed according to current European guidelines. At admission, clinical and biological characteristics were collected; <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> serology and <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> detection were retrospectively performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010four patients were included. Mean age was 50.8\u00a0\u00b1\u00a09.6\u00a0years, 65.5% were male, 91.7% were cirrhotic and 33.3% presented with encephalopathy. Mean <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> and Maddrey scores were respectively 32.4\u00a0\u00b1\u00a011.4 and 73.3\u00a0\u00b1\u00a037. Liver biopsy showed mild, moderate and severe hepatitis in 25 (29.8%), 23 (27.4%) and 32 (38.1%) patients respectively. Steroids were given to 61 patients (72.6%) of whom 35 (57.4%) presented corticoresistance (mean Lille score: 0.78\u00a0\u00b1\u00a00.21). During hospitalization, 24 patients (28.6%) died and 11 (13.1%) were transplanted. Three patients (3.6%) presented markers of acute <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> infection and 21 (25%) markers of past <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> infection. Patient with acute infection were men, cirrhotic, and 2\/3 presented with encephalopathy. Steroids were given to two patients without any response. The third patient died. None were transplanted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A substantial proportion of patients with severe <jats:styled-content style=\"fixed-case\">AAH<\/jats:styled-content> had markers of acute <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> infection, with similar clinical presentation and outcomes. Larger studies are needed to evaluate <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> impact on <jats:styled-content style=\"fixed-case\">AAH<\/jats:styled-content> management, resistance to steroids, and outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12610","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T10:36:51Z","timestamp":1402051011000},"page":"870-875","source":"Crossref","is-referenced-by-count":25,"title":["Hepatitis E infection in patients with severe acute alcoholic hepatitis"],"prefix":"10.1111","volume":"35","author":[{"given":"St\u00e9phanie","family":"Haim\u2010Boukobza","sequence":"first","affiliation":[{"name":"Virologie CNR des h\u00e9patites A et E AP\u2010HP, H\u00f4pital Paul Brousse Villejuif 94804 France"},{"name":"UMR\u2010S 785 Univ Paris\u2010Sud Le Kremlin Bic\u00eatre 94275 France"},{"name":"INSERM U785 Villejuif 94804 France"},{"name":"Hepatinov Villejuif F94800 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