{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:36:51Z","timestamp":1770485811575,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T00:00:00Z","timestamp":1404777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>A simple and reproducible evaluation of non diagnostic histological lesions related to prognosis remains crucial in primary biliary cirrhosis (<jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content>). Presently there is no satisfactory simple scoring system analysing them reliably. We elaborated a semi\u2010quantitative scoring system that assesses fibrosis, lymphocytic interface hepatitis (<jats:styled-content style=\"fixed-case\">LIH<\/jats:styled-content>) and ductopenia, separately. This study was aimed to evaluate its intra\/interobserver reproducibility and its correlation with the main biochemical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Liver biopsies from 33 consecutive newly diagnosed <jats:styled-content style=\"fixed-case\">PBC<\/jats:styled-content> patients were independently analysed by five liver pathologists. Fibrosis was classified into five stages (portal\/periportal fibrosis\/few septa\/numerous septa\/cirrhosis) and <jats:styled-content style=\"fixed-case\">LIH<\/jats:styled-content> into four grades. The bile duct ratio (<jats:styled-content style=\"fixed-case\">BDR<\/jats:styled-content>), i.e. ratio of the number of portal tracts with ducts to total number of portal tracts, Ludwig's and Scheuer's stages were evaluated. Intra and interobserver agreements were assessed. Histological results were correlated to the biochemical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients had an early disease on clinical and biological parameters. The biopsies measured 23\u00a0mm on average (range 12 \u2013 40\u00a0mm). Intraobserver reproducibility was substantial for fibrosis (\u03ba\u00a0=\u00a00.68), <jats:styled-content style=\"fixed-case\">LIH<\/jats:styled-content> (\u03ba\u00a0=\u00a00.69) and <jats:styled-content style=\"fixed-case\">BDR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u00a0=\u00a00.69). Interobserver agreement for fibrosis was fair with the 5\u2010class system (\u03ba\u00a0=\u00a00.36), moderate with a 4\u2010class system (\u03ba\u00a0=\u00a00.56). moderate for <jats:styled-content style=\"fixed-case\">LIH<\/jats:styled-content> (\u03ba\u00a0=\u00a00.59) and <jats:styled-content style=\"fixed-case\">BDR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>\u00a0=\u00a00.50). Ludwig's and Scheuer's staging showed a fair interobserver agreement (\u03ba\u00a0=\u00a00.32, \u03ba\u00a0=\u00a00.31 respectively). Our system showed better correlations with biochemistry than Ludwig's and Scheuer's systems did.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This simple scoring system, assessing fibrosis, <jats:styled-content style=\"fixed-case\">LIH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BDR<\/jats:styled-content> separately, has a substantial intraobserver and a moderate interobserver reproducibility. Its prognostic relevance has to be evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12620","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T17:10:03Z","timestamp":1403025003000},"page":"652-659","source":"Crossref","is-referenced-by-count":23,"title":["Primary biliary cirrhosis: proposal for a new simple histological scoring system"],"prefix":"10.1111","volume":"35","author":[{"given":"Dominique","family":"Wendum","sequence":"first","affiliation":[{"name":"Anatomie Pathologique AP\u2010HP H\u00f4pital St Antoine Paris France"},{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Yves","family":"Bo\u00eblle","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 Paris France"},{"name":"Sant\u00e9 Publique AP\u2010HP H\u00f4pital St Antoine Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bedossa","sequence":"additional","affiliation":[{"name":"Anatomie pathologique AP\u2010HP H\u00f4pital Beaujon Clichy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie\u2010Serge","family":"Zafrani","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pathologie AP\u2010HP Groupe Hospitalier Henri Mondor Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Charlotte","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 Paris France"},{"name":"Anatomie pathologique AP\u2010HP \u2010 H\u00f4pital Piti\u00e9\u2010Salp\u00e9tri\u00e8re Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Christine","family":"Saint\u2010Paul","sequence":"additional","affiliation":[{"name":"Anatomie pathologique CHU Nice Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Michalak","sequence":"additional","affiliation":[{"name":"CHU Angers Anatomie pathologique Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Chazouill\u00e8res","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, UPMC Universit\u00e9 Paris 06 Paris France"},{"name":"H\u00e9patologie Centre de r\u00e9f\u00e9rence des maladies inflammatoires des voies biliaires AP\u2010HP, H\u00f4pital St Antoine Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Corpechot","sequence":"additional","affiliation":[{"name":"H\u00e9patologie Centre de r\u00e9f\u00e9rence des maladies inflammatoires des voies biliaires AP\u2010HP, H\u00f4pital St Antoine Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61965-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105303242204"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290301"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.01.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.029"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22428"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.031"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22906"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510290444"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31880"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.216"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200104"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02537.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432479"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/003591576706001205"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280203"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280206"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.935"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80226-6"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25889"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02500.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31827234e4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.09.017"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02087659"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20535"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.49.7.556"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12620","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12620","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:46:15Z","timestamp":1695563175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,8]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/liv.12620"],"URL":"https:\/\/doi.org\/10.1111\/liv.12620","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,8]]}}}