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The aim of this study was to provide an overview of the 2\u2010year clinical outcomes among initial survivors and liver transplant (<jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content>) recipients that were alive 3\u00a0weeks after enrolment in the Acute Liver Failure Study Group (<jats:styled-content style=\"fixed-case\">ALFSG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Outcomes in adult <jats:styled-content style=\"fixed-case\">ALFSG<\/jats:styled-content> patients that were enrolled between 1998 and 2010 were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two\u2010year patient survival was significantly higher in the 262 <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients (92.4%) compared to the 306 acetaminophen (<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content>) spontaneous survivors (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>) (89.5%) and 200 non\u2010<jats:styled-content style=\"fixed-case\">APAP SS<\/jats:styled-content> (75.5%) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The causes of death were similar in the three groups but the time to death was significantly longer in the <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Independent predictors of 2\u2010year mortality in the <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> group were a high serum phosphate level and patient age (c\u2010statistic\u00a0=\u00a00.65 (0.54, 0.76)), patient age and days from jaundice to <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> onset in the non\u2010<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> group (c\u2010statistic\u00a0=\u00a00.69 (0.60, 0.78)), and patient age, days from jaundice, and higher coma grade in the <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients (c\u2010statistic\u00a0=\u00a00.74 (0.61, 0.87)). The <jats:styled-content style=\"fixed-case\">LT<\/jats:styled-content> recipients were significantly more likely to be employed and have a higher educational level (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Two\u2010year outcomes in initial survivors of <jats:styled-content style=\"fixed-case\">ALF<\/jats:styled-content> are generally good but non\u2010<jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> patients have a significantly lower survival which may relate to pre\u2010existing medical comorbidities. Spontaneous survivors with <jats:styled-content style=\"fixed-case\">APAP<\/jats:styled-content> overdose experience substantial morbidity during follow\u2010up from ongoing psychiatric and substance abuse issues.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12632","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T14:40:35Z","timestamp":1405435235000},"page":"370-380","source":"Crossref","is-referenced-by-count":63,"title":["Two\u2010year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study"],"prefix":"10.1111","volume":"35","author":[{"given":"Robert J.","family":"Fontana","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine University of Michigan Medical Center Ann Arbor MI 48109\u20100362 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlyn","family":"Ellerbe","sequence":"additional","affiliation":[{"name":"Division of 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