{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:08:19Z","timestamp":1777496899967,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T00:00:00Z","timestamp":1416441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Society of Organ Transplantation"},{"name":"Prof. Micha\u00ebl-van Vloten Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>We studied new\u2010onset diabetes after transplantation (<jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content>) in liver transplantation with grafts donated after brain death (<jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content>) or circulatory death (<jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content>), focusing on the early post\u2010transplant period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 430 non\u2010diabetic primary liver transplant recipients [<jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a090 (21%)] were followed up for 30\u00a0months (range 5\u201369). <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content> was defined as the composite endpoint of one of following: (i) Two non\u2010fasting plasma glucose levels &gt; 11.1\u00a0mmol\/L\u00a0\u2265\u00a030\u00a0days apart, (ii) oral hypoglycaemic drugs \u2265 30\u00a0days consecutively (iii) insulin therapy \u2265 30\u00a0days and (iv) HbA1c \u2265 48\u00a0mmol\/L. Resolution of <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content> was defined as cessation of treatment or hyperglycaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total of 81\/430 (19%) patients developed <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content>. Incidence and resolution of <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content> over time showed significantly different patterns between <jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DBD<\/jats:styled-content> liver graft recipients; early occurrence, high peak incidence and early resolution were seen in <jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content>. In multivariate logistic regression including age, ethnicity, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>, tacrolimus level and pulsed steroids, only <jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content> was independently associated with <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content> at day 15 post\u2010transplant (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 6.5, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.3\u201318.4, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), whereas age and pulsed steroids were significant factors between 30\u201390\u00a0days. Combined in multivariate Cox regression model for <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content>\u2010free survival, graft type, age and pulsed steroids were each independent predictor for decreased <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content>\u2010free survival in the first 90\u2010postoperative days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early peak of <jats:styled-content style=\"fixed-case\">NODAT<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">DCD<\/jats:styled-content> graft recipients is a novel finding, occurring independently from known risk factors. Donor warm ischaemia and impact on insulin sensitivity should be further studied and could perhaps be associated with graft function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12706","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T12:09:09Z","timestamp":1414411749000},"page":"1739-1747","source":"Crossref","is-referenced-by-count":15,"title":["Early occurrence of new\u2010onset diabetes after transplantation is related to type of liver graft and warm ischaemic injury"],"prefix":"10.1111","volume":"35","author":[{"given":"Hermien","family":"Hartog","sequence":"first","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine J.H.","family":"May","sequence":"additional","affiliation":[{"name":"Diabetes Center Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Corbett","sequence":"additional","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Phillips","sequence":"additional","affiliation":[{"name":"Diabetes Center Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy W.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Institute of Biomedical research University of Birmingham Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hynek","family":"Mergental","sequence":"additional","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Isaac","sequence":"additional","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Bramhall","sequence":"additional","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius F.","family":"Mirza","sequence":"additional","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Muiesan","sequence":"additional","affiliation":[{"name":"Liver Unit Queen Elizabeth Hospital Birmingham Edgbaston Birmingham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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