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However, under conditions similar to those <jats:italic>in vivo<\/jats:italic>, primary hemostasis and thrombin production do not appear to be decreased in patients with cirrhosis, particularly when the platelet count is above 75\u00a0000\/\u03bcl. Furthermore, there is laboratory and epidemiological evidence of a mild procoagulant and prothrombotic state in patients with cirrhosis. Bleeding is mainly because of portal hypertension rather than defective hemostasis. There is some evidence that anticoagulation therapy is not associated with an excess of severe bleeding and that it could improve the outcome in patients without portal vein thrombosis. At present, there is no clear evidence that portal vein thrombosis is responsible for the progression of liver disease and that anticoagulation therapy would improve the outcome of patients with portal vein thrombosis.<\/jats:p>","DOI":"10.1111\/liv.12723","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T10:26:34Z","timestamp":1419243994000},"page":"139-144","source":"Crossref","is-referenced-by-count":30,"title":["The coagulation system in patients with end\u2010stage liver disease"],"prefix":"10.1111","volume":"35","author":[{"given":"Dominique\u2010C.","family":"Valla","sequence":"first","affiliation":[{"name":"DHU UNITY Service d'H\u00e9patologie H\u00f4pital Beaujon AP\u2010HP Clichy\u2010la\u2010Garenne France"},{"name":"INSERM U1149 CRI Universit\u00e9 Paris\u2010Diderot Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010E.","family":"Rautou","sequence":"additional","affiliation":[{"name":"DHU UNITY Service d'H\u00e9patologie H\u00f4pital Beaujon AP\u2010HP Clichy\u2010la\u2010Garenne France"},{"name":"INSERM U970 Paris Cardiovascular Research Center Universit\u00e9 Paris Descartes; Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04429.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011170"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.06.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21732"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21680"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.034"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04182.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.036"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.02801.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.06.018"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60004-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21907"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2014.03.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20940"},{"key":"e_1_2_8_17_1","first-page":"CD006007","article-title":"Antifibrinolytic amino acids for upper gastrointestinal bleeding in patients with acute or chronic liver disease","volume":"9","author":"Marti\u2010Carvajal AJ","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_18_1","first-page":"CD004792","article-title":"Vitamin K for upper gastrointestinal bleeding in patients with acute or chronic liver diseases","volume":"9","author":"Marti\u2010Carvajal AJ","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_19_1","first-page":"CD004887","article-title":"Human recombinant activated factor VII for upper gastrointestinal bleeding in patients with liver diseases","volume":"3","author":"Marti\u2010Carvajal AJ","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12038"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-011-0528-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21510"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110709"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22742"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91024-C"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.2.270"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/hep.1840180514","article-title":"Randomized controlled trial of desmopressin plus terlipressin vs. terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: a multicenter, double\u2010blind study. 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