{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:33:18Z","timestamp":1788564798382,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n \n Primary biliary cirrhosis and Primary sclerosing cholangitis are autoimmune cholestatic liver diseases sharing a lot in common, including a significant impairment of patients\u2019 health\u2010related quality of life\n HRQ<\/jats:styled-content>\n oL\n HRQ<\/jats:styled-content>\n oL in\n PBC<\/jats:styled-content>\n is assessed with disease\u2010specific\n PBC<\/jats:styled-content>\n \u201040 and\n PBC<\/jats:styled-content>\n \u201027 questionnaires. A\n PSC<\/jats:styled-content>\n \u2010specific questionnaire has not been developed. Neither\n PBC<\/jats:styled-content>\n \u201040 nor\n PBC<\/jats:styled-content>\n \u201027s applicability for\n PSC<\/jats:styled-content>\n has been evaluated. We applied these three questionnaires for\n HRQ<\/jats:styled-content>\n oL assessment in a large homogenous cohort of\n PSC<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n This cross\u2010sectional study enrolled 102 Caucasian\n PSC<\/jats:styled-content>\n s and 53 matched healthy controls and measured\n HRQ<\/jats:styled-content>\n oL using generic\n SF<\/jats:styled-content>\n \u201036, and disease\u2010specific (\n PBC<\/jats:styled-content>\n \u201040\/\n PBC<\/jats:styled-content>\n \u201027) questionnaires.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n (i)\n SF<\/jats:styled-content>\n \u201036. Most\n SF<\/jats:styled-content>\n \u201036 domains were significantly lower in\n PSC<\/jats:styled-content>\n s than controls. Physical Functioning and Mental Component Summary scores were significantly lower in female patients and correlated negatively with age but not with concurrent inflammatory bowel disease. Cirrhosis was associated with lower Physical Functioning, Role Physical, General Health, Vitality and Physical Component Summary. (ii)\n PBC<\/jats:styled-content>\n \u201040 and\n PBC<\/jats:styled-content>\n \u201027. Both tools showed similar\n HRQ<\/jats:styled-content>\n oL impairment scoring. Fatigue and Cognitive were impaired in female patients. Several correlations existed between\n HRQ<\/jats:styled-content>\n oL and laboratory parameters, including cholestatic tests and Itch. Cirrhosis correlated with Other symptoms and Fatigue\n PBC<\/jats:styled-content>\n \u201040. (iii)\n PBC<\/jats:styled-content>\n \u201040 vs\n PBC<\/jats:styled-content>\n \u201027. Strong correlations among most domains of both questionnaires were seen, as well as between (iv)\n SF<\/jats:styled-content>\n \u201036 vs\n PBC<\/jats:styled-content>\n \u201040 or\n SF<\/jats:styled-content>\n \u201036 vs\n PBC<\/jats:styled-content>\n \u201027.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This is the first study directly comparing\n PBC<\/jats:styled-content>\n \u201040,\n PBC<\/jats:styled-content>\n \u201027 and\n SF<\/jats:styled-content>\n \u201036 in\n PSC<\/jats:styled-content>\n .\n PSC<\/jats:styled-content>\n patients, especially females, show\n HRQ<\/jats:styled-content>\n oL impairment.\n PBC<\/jats:styled-content>\n \u201040 and\n PBC<\/jats:styled-content>\n \u201027 questionnaires could be of potential use for\n HRQ<\/jats:styled-content>\n oL assessment in\n PSC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.12730","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T02:55:16Z","timestamp":1415760916000},"page":"1764-1771","source":"Crossref","is-referenced-by-count":40,"title":["Prospective evaluation of\n PBC<\/scp>\n \u2010specific health\u2010related quality of life questionnaires in patients with primary sclerosing cholangitis"],"prefix":"10.1111","volume":"35","author":[{"given":"Joanna","family":"Raszeja\u2010Wyszomirska","sequence":"first","affiliation":[{"name":"Liver and Internal Medicine Unit Department of General Transplant and Liver Surgery of the Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wunsch","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Biochemistry Pomeranian Medical University Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Department of General Transplant and Liver Surgery of the Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini I","family":"Rigopoulou","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies King's College London School of Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Bogdanos","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies King's College London School of Medicine King's College Hospital London UK"},{"name":"Department of Medicine School of Health Sciences Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Milkiewicz","sequence":"additional","affiliation":[{"name":"Liver and Internal Medicine Unit Department of General Transplant and Liver Surgery of the Medical University of Warsaw Warsaw Poland"},{"name":"Department of Clinical and Molecular Biochemistry Pomeranian Medical University Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"issue":"1","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"S241","DOI":"10.1016\/S0168-8278(09)60658-9","article-title":"High prevalence of fatigue in patients with sclerosing cholangitis","volume":"50","author":"Al\u2010Harthy N","year":"2009","journal-title":"Hepatology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.080317"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21230"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20276"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0350"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.065862"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.01.004"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.12.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23683"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01774.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.01.025"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.025155"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-014-8427-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60096-3"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21699"},{"key":"e_1_2_8_19_1","first-page":"1571","article-title":"The short inflammatory bowel disease questionnaire: a quality of life instrument for community physicians managing inflammatory bowel disease. 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