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In this study, we assessed the treatment efficacy of combining Peg <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> \u03b1\u20102a with Adefovir (<jats:styled-content style=\"fixed-case\">CPIA<\/jats:styled-content>) in chronic <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> infected pregnant women with normal levels of <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> and high levels of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Chronic hepatitis B pregnant women with normal levels of <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> and high levels of <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> were treated with Telbivudine during the third trimester of their pregnancy. After childbirth, based on serological and virological parameters, the patients were either switched to <jats:styled-content style=\"fixed-case\">CPIA<\/jats:styled-content> treatment for 96\u00a0weeks or stopped Telbivudine treatment and followed for 48\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 68 patients were enrolled in this study. Thirty (30\/68) of them were switched to <jats:styled-content style=\"fixed-case\">CPIA<\/jats:styled-content> treatment after childbirth, 93.3% (28\/30) of them achieved virological response, 56.7% (17\/30) achieved <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg seroclearance and 26.7% (8\/30) cleared <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg. The <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg levels before <jats:styled-content style=\"fixed-case\">CPIA<\/jats:styled-content> treatment were negatively associated with <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg seroclearance. <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg and <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg levels in week 12 and week 24 after <jats:styled-content style=\"fixed-case\">CPIA<\/jats:styled-content> treatment were negatively associated with <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg seroclearance. Thirty\u2010eight (38\/68) patients did not receive antiviral treatment after childbirth, and none of them had <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg or <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>sAg clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High rates of viral response and clearance were achieved in chronic hepatitis B pregnant woman with normal levels of <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> and high levels of <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> treated by <jats:styled-content style=\"fixed-case\">CPIA<\/jats:styled-content> after childbirth. (231 words).<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12753","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T08:53:30Z","timestamp":1417424010000},"page":"1692-1699","source":"Crossref","is-referenced-by-count":29,"title":["Effect of Peg\u2010interferon \u03b1\u20102a combined with Adefovir in HBV postpartum women with normal levels of ALT and high levels of HBV DNA"],"prefix":"10.1111","volume":"35","author":[{"given":"Junfeng","family":"Lu","sequence":"first","affiliation":[{"name":"International Medical Department Beijing Youan Hospital Capital Medical University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shibin","family":"Zhang","sequence":"additional","affiliation":[{"name":"International Medical Department Beijing Youan Hospital Capital Medical University Beijing 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