{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:17:52Z","timestamp":1765268272405},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"l'Association Pour la Recherche en Nephrologie"},{"name":"Inserm and the \u2018Direction R\u00e9gionale Clinique\u2019"},{"name":"Inserm and the \u2018Direction de la Recherch\u00e9 M\u00e9dicale et Innovation\u2019"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Chronic kidney disease (<jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>) is a common complication after liver transplantation. Kidney biopsies cannot be easily performed before liver transplantation to predict patients at high risk for <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. The aim of our study was to determine whether pre\u2010, peri\u2010 and post\u2010transplant factors, as well as peptides present in preliver transplant urine samples were associated with loss in kidney function at 6\u00a0months post\u2010transplantation using proteome analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients who underwent a liver transplantation and that had pretransplant glomerular filtration rate (<jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content>) value of \u226560 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73 m\u00b2 (<jats:styled-content style=\"fixed-case\">MDRD<\/jats:styled-content>) were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GFR<\/jats:styled-content> decreased significantly after transplantation. At month 6 post\u2010transplantation, 40 patients displayed a <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>, i.e. <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> of &lt;60 <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\/min\/1.73 m\u00b2, while the other 40 patients did not. Although thousands of peptides were identified, none was significantly associated with the development of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> at 6\u00a0months after liver transplantation. Moreover, using a urinary peptidome classifier to detect preexisting <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>, no difference was found in <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> scores between the 2 groups. After analysis of a large number of pre\u2010, peri\u2010 and post\u2010transplant parameters, viral hepatitis as a cause for liver transplantation was the sole independent predictive factor for <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content>. No difference in peptides with differential urinary abundance between patients who received a graft for virus related liver disease vs. all other causes of liver disease was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Urinary peptidome analysis before liver transplantation failed to identify a peptide pattern associated with the development of <jats:styled-content style=\"fixed-case\">CKD<\/jats:styled-content> at 6\u00a0months after liver transplantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12763","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T07:50:01Z","timestamp":1418802601000},"page":"1893-1901","source":"Crossref","is-referenced-by-count":7,"title":["Pretransplant urinary proteome analysis does not predict development of chronic kidney disease after liver transplantation"],"prefix":"10.1111","volume":"35","author":[{"given":"David","family":"Milongo","sequence":"first","affiliation":[{"name":"Department of Nephrology and Organ Transplantation CHU Rangueil Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Loup","family":"Bascands","sequence":"additional","affiliation":[{"name":"U1048, Institut of Cardiovascular and Metabolic Disease Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Toulouse France"},{"name":"Universit\u00e9 Toulouse III Paul\u2010Sabatier Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine","family":"Huart","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ Transplantation CHU Rangueil Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laure","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Organ 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