{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:29:16Z","timestamp":1790735356040,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Liver Outcomes Research Fund"},{"DOI":"10.13039\/100012416","name":"Inova Health System","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012416","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aims<\/jats:title>\n                    <jats:p>In the past three decades, there have been major advances in the procedure and candidate selection for liver transplantation. The aim of this study was to assess the changes in outcomes of liver transplantations in the Unites States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This observational study uses the Scientific Registry of Transplant Recipients (\n                      <jats:styled-content style=\"fixed-case\">SRTR<\/jats:styled-content>\n                      ) that includes all liver transplants from 1987 to 2013 (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0108\u00a0707 adults).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four study cycles were introduced: 1987\u20131993, 1994\u20132000, 2001\u20132006, 2007\u20132013. The length of inpatient stay for receiving liver transplant substantially shortened (42\u201320\u00a0days), and so did the rate of acute post\u2010transplant rejections (33\u20134%). The use of high risk donors and donors with chronic diseases increased significantly. Of transplant outcomes, despite recently reported unfavourable changes in clinico\u2010demographic profile of liver transplant recipients (older age, substantial increases in all major comorbidities), the proportion of patients discharged alive increased from 78.2 to 91.8%. On the other hand, post\u2010discharge 1\u2010, 3\u2010 and 5\u2010year mortality varied between 6.7 and 8.0%, 15.2 to 17.2% and 22.5 to 24.5%, respectively, and no consistent trend was found. Despite this, the rates of graft failure decreased: an approximately two\u2010fold decrease in 1\u00a0year graft loss, and a 1.6\u2010fold decrease in 5\u00a0year graft loss were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite all improvements in liver transplant technique and patient management, the changes in post\u2010transplant outcomes vary. While inpatient mortality, graft losses and post\u2010transplant infect\u2010ion rates improved substantially, post\u2010discharge mortality remains stable because of increasing losses to competing risks in patients with non\u2010liver comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/liv.12779","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T07:53:17Z","timestamp":1420444397000},"page":"2036-2041","source":"Crossref","is-referenced-by-count":33,"title":["The outcomes of adult liver transplants in the United States from 1987 to 2013"],"prefix":"10.1111","volume":"35","author":[{"given":"Maria","family":"Stepanova","sequence":"first","affiliation":[{"name":"Center for Liver Diseases Department of Medicine Inova Fairfax Hospital Falls Church VA USA"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homan","family":"Wai","sequence":"additional","affiliation":[{"name":"Center for Liver Diseases Department of Medicine Inova Fairfax Hospital Falls Church VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy","family":"Saab","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at the University of California at Los Angeles Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alita","family":"Mishra","sequence":"additional","affiliation":[{"name":"Center for Liver Diseases Department of Medicine Inova Fairfax Hospital Falls Church VA USA"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chapy","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"Center for Liver Diseases Department of Medicine Inova Fairfax Hospital Falls Church VA USA"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zobair M.","family":"Younossi","sequence":"additional","affiliation":[{"name":"Center for Liver Diseases Department of Medicine Inova Fairfax Hospital Falls Church VA USA"},{"name":"Betty and Guy Beatty Center for Integrated Research Inova Health System Falls Church VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,21]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"659","article-title":"Homotransplantation of the Liver in Humans","volume":"117","author":"Starzl TE","year":"1963","journal-title":"Surg Gynecol Obstet."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2927"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107303050507"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910123211505"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e3283457d5d"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01758.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0070"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20906"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2008.05.072"},{"key":"e_1_2_8_12_1","unstructured":"OPTN\/SRTR2011Annual Data Report. pp.73\u2010102. Available at:http:\/\/srtr.transplant.hrsa.gov\/annual_reports\/2011\/Default.aspx. Accessed May 20 2014."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182a15db4"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.2903"},{"key":"e_1_2_8_15_1","unstructured":"RogersMF SimondsRJ LawtonKE MoseleyRR JonesWK.Guidelines for Preventing Transmission of Human Immunodeficiency Virus Through Transplantation of Human Tissue and Organs.MMWR1994; 43(No. RR\u20108):1\u201317."},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.03.020"},{"key":"e_1_2_8_17_1","unstructured":"CDC\/NCHS National Vital Statistics System.Deaths percent of total deaths and death rates for the 15 leading causes of death in 5\u2010year age groups by race and sex: United States 2010.http:\/\/www.cdc.gov\/nchs\/data\/dvs\/LCWK1_2010.pdf. Accessed May 20 2014."}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12779","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:05:05Z","timestamp":1695560705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,21]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/liv.12779"],"URL":"https:\/\/doi.org\/10.1111\/liv.12779","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,21]]}}}