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These entities are both clinically and pathophysiologically different: the hepatopulmonary syndrome is characterized by abnormal pulmonary vasodilation and right\u2010to\u2010left shunting resulting in gas exchange abnormalities, whereas portopulmonary hypertension is caused by pulmonary artery vasoconstriction leading to hemodynamic failure. As both hepatopulmonary syndrome and portopulmonary hypertension are associated with significantly increased morbidity and mortality, and\u00a0as these patients are commonly asymptomatic, all liver transplantation candidates should be actively screened for the presence of these two complications. The aim of is this review is to provide an overview on the hepatopulmonary syndrome and portopulmonary hypertension with primary focus on diagnosis and recent knowledge regarding pathogenesis and therapeutic targets.<\/jats:p>","DOI":"10.1111\/liv.12791","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T11:20:12Z","timestamp":1422357612000},"page":"1646-1660","source":"Crossref","is-referenced-by-count":93,"title":["Hepatopulmonary syndrome and portopulmonary hypertension: recent knowledge in pathogenesis and overview of clinical assessment"],"prefix":"10.1111","volume":"35","author":[{"given":"Sarah","family":"Raevens","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Geerts","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Van Steenkiste","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ghent University Hospital Ghent Belgium"},{"name":"Department of Gastroenterology and Hepatology Maria Middelares Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Verhelst","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Van Vlierberghe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ghent University Hospital Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Colle","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ghent University Hospital Ghent Belgium"},{"name":"Department of Gastroenterology and Hepatology Algemeen Stedelijk Ziekenhuis ASZ Aalst Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,16]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"133","article-title":"Prevalence and reversibility of the hepatopulmonary syndrome after liver transplantation. 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