{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:47:58Z","timestamp":1695620878081},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,4,17]],"date-time":"2015-04-17T00:00:00Z","timestamp":1429228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>To evaluate the efficacy of tenofovir in chronic hepatitis B (<jats:styled-content style=\"fixed-case\">CHB<\/jats:styled-content>) patients with adefovir resistance (<jats:styled-content style=\"fixed-case\">ADF<\/jats:styled-content>\u2010R) and suboptimal response to adefovir (<jats:styled-content style=\"fixed-case\">ADF<\/jats:styled-content>\u2010S).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nucleos(t)ide analogue (<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>)\u2010na\u00efve patients and patients with previous adefovir failure receiving tenofovir therapy for at least 6\u00a0months were included in the study. Biochemical and virological tests were obtained at baseline and 3\u2010month intervals in the first year and every 6\u00a0months thereafter. The primary outcome measure was complete virological response (<jats:styled-content style=\"fixed-case\">CVR<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">HBVDNA<\/jats:styled-content>\u00a0&lt;\u00a020 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/ml). <jats:styled-content style=\"fixed-case\">CVR<\/jats:styled-content> rates were calculated by Kaplan\u2013Meier analysis, and a multivariate Cox proportional hazard model was generated to find out factors independently associated with <jats:styled-content style=\"fixed-case\">CVR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 165 patients (118 men, mean age 42\u00a0\u00b1\u00a012, 64 <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg<jats:sup>+<\/jats:sup>) were included in the study. There were 105 patients in <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010na\u00efve, 32 patients in <jats:styled-content style=\"fixed-case\">ADF<\/jats:styled-content>\u2010S and 28 patients in <jats:styled-content style=\"fixed-case\">ADF<\/jats:styled-content>\u2010R groups. All patients in the <jats:styled-content style=\"fixed-case\">ADF<\/jats:styled-content>\u2010R group had multidrug resistance patterns. Mean duration of tenofovir treatment was 29\u00a0\u00b1\u00a014 months. <jats:styled-content style=\"fixed-case\">CVR<\/jats:styled-content> rates in <jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>\u2010na\u00efve, <jats:styled-content style=\"fixed-case\">ADF<\/jats:styled-content>\u2010S and <jats:styled-content style=\"fixed-case\">ADF<\/jats:styled-content>\u2010R groups were 65% vs. 75% vs. 58% at 12th month, 77% vs. 87% vs. 79% at 24th month and 83% vs. 94% vs. 79% at 36th month respectively. According to multivariate Cox regression model, <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>eAg positivity (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.56, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.36\u20130.86, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.008), high baseline <jats:styled-content style=\"fixed-case\">HBVDNA<\/jats:styled-content> level (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.64, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.55\u20130.74, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">ADF<\/jats:styled-content>\u2010R (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a00.47, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.28\u20130.81, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) were independent predictors for <jats:styled-content style=\"fixed-case\">CVR<\/jats:styled-content>. Seven patients encountered mild renal dysfunction and were managed by dose adjustments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CVR<\/jats:styled-content> rates during the follow\u2010up show that tenofovir has a decreased, yet still potent <jats:italic>in vivo<\/jats:italic> efficacy against multidrug\u2010resistant strains of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12831","type":"journal-article","created":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T16:34:33Z","timestamp":1426869273000},"page":"2265-2274","source":"Crossref","is-referenced-by-count":2,"title":["Tenofovir disoproxil fumarate has a substantial efficacy against multidrug\u2010resistant strains of hepatitis B virus"],"prefix":"10.1111","volume":"35","author":[{"given":"Bulent","family":"Baran","sequence":"first","affiliation":[{"name":"Department of Gastroenterology 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