{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T17:08:45Z","timestamp":1780506525351,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T00:00:00Z","timestamp":1430784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","award":["HY\u20102010\u2010G"],"award-info":[{"award-number":["HY\u20102010\u2010G"]}],"id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>To assess the correlation between liver stiffness measurement (<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>) by real\u2010time shear wave elastography (<jats:styled-content style=\"fixed-case\">SWE<\/jats:styled-content>) and hepatic venous pressure gradient (<jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>) and to investigate the diagnostic performance of <jats:styled-content style=\"fixed-case\">SWE<\/jats:styled-content> for predicting clinically significant and severe portal hypertension (<jats:styled-content style=\"fixed-case\">CSPH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 115 cirrhotic patients with haemodynamic measurement were consecutively collected. Liver stiffness (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>) was measured using <jats:styled-content style=\"fixed-case\">SWE<\/jats:styled-content> by repeated performance five times per patient, and the median value and interquartile range of the parameters on the same day of <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> measurement was calculated. <jats:styled-content style=\"fixed-case\">CSPH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPH<\/jats:styled-content> were defined as a <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> \u226510\u00a0mmHg and \u226512\u00a0mmHg respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 92 patients (male, 63; mean age, 53\u00a0\u00b1\u00a011.9\u00a0years) were eligible for analysis. <jats:styled-content style=\"fixed-case\">CSPH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPH<\/jats:styled-content> were detected in 77 patients (83.7%) and 66 patients (71.5%) respectively. <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> were significantly correlated with <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> in the overall, <jats:styled-content style=\"fixed-case\">CSPH<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">SPH<\/jats:styled-content> patients (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.646, 0.574 and 0.424 respectively; all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). With ascites, the correlation coefficient did not decrease (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.587). The <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>s of <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> was 0.819 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.725\u20130.892) for <jats:styled-content style=\"fixed-case\">CSPH<\/jats:styled-content> and 0.867 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.780\u20130.928) for <jats:styled-content style=\"fixed-case\">SPH<\/jats:styled-content>. The cut\u2010off values for determining <jats:styled-content style=\"fixed-case\">CSPH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPH<\/jats:styled-content> were 15.2\u00a0kPa (Sensitivity, 85.7%; Specificity, 80.0%) and 21.6 <jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a (Sensitivity, 83.3%; Specificity, 80.8%) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In cirrhotic patients, <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> by <jats:styled-content style=\"fixed-case\">SWE<\/jats:styled-content> is highly correlated with <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> value regardless of ascites. <jats:styled-content style=\"fixed-case\">SWE<\/jats:styled-content> is a new reliable non\u2010invasive diagnostic tool to predict <jats:styled-content style=\"fixed-case\">CSPH<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SPH<\/jats:styled-content>, even in cirrhotic patients with ascites.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12846","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T12:27:04Z","timestamp":1429100824000},"page":"2416-2424","source":"Crossref","is-referenced-by-count":73,"title":["Evaluation of portal hypertension by real\u2010time shear wave elastography in cirrhotic patients"],"prefix":"10.1111","volume":"35","author":[{"given":"Tae Yeob","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital and Hanyang University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Kyoung","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Radiology and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 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