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The aims of this study were to determine whether there has been an increase in the number of acute <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infections in different parts of Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seroconversion was defined as an <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010antibody test change from negative to positive within the observation period in Euro<jats:styled-content style=\"fixed-case\">SIDA<\/jats:styled-content>. Binomial regression was performed to determine factors associated with being tested for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seroconversion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 223 <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seroconversions\u00a0were observed from 16\u00a0188 tests [1.38% (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.20\u20131.56)] among 5736 patients between 2002 and 2013. Overall the odds of acquiring <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection increased by 4% per year (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.04 [95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.99\u20131.09]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.10). Overall 63.2% (141\/223) of all seroconversions were seen among <jats:styled-content style=\"fixed-case\">MSM<\/jats:styled-content>. Similar patterns were observed across all European regions (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.69, test for interaction) and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> transmission risks groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.69, test for interaction). In multivariate analysis, North, South and East Europe had higher odds of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seroconversion compared with Western Europe [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.90 (1.28\u20132.81), 1.55 (0.99\u20132.45) and 1.86 (1.21\u20132.84); <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0014, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.058 and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0044 respectively].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within Euro<jats:styled-content style=\"fixed-case\">SIDA<\/jats:styled-content> a significant increase in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> seroconversions can be observed after accounting for increased levels of testing for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> in recent years. This\u00a0highlights the need for increased <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> prevention efforts among <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive persons in Europe.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12848","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T12:38:50Z","timestamp":1429101530000},"page":"2384-2391","source":"Crossref","is-referenced-by-count":30,"title":["Hepatitis C seroconversions in <scp>HIV<\/scp> infection across Europe: which regions and patient groups are affected?"],"prefix":"10.1111","volume":"35","author":[{"given":"Christoph","family":"Boesecke","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Grint","sequence":"additional","affiliation":[{"name":"UCL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Soriano","sequence":"additional","affiliation":[{"name":"Hospital Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens D.","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Rheumatology CHIP Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"d'Arminio Monforte","sequence":"additional","affiliation":[{"name":"Istituto Di Clinica Malattie Infettive e Tropicale Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Mitsura","sequence":"additional","affiliation":[{"name":"Gomel State Medical University Gomel Belarus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Chentsova","sequence":"additional","affiliation":[{"name":"Kiev Centre for AIDS Kiev Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesnadarjan","family":"Hadziosmanovic","sequence":"additional","affiliation":[{"name":"Klinicki Centar Univerziteta Sarajevo Sarajevo Bosnia\u2010Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Rheumatology CHIP Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Mocroft","sequence":"additional","affiliation":[{"name":"UCL London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Rheumatology CHIP Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen K.","family":"Rockstroh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I Bonn University Hospital Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EuroSIDA in EuroCoord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2012.08.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/596770"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2003.008532"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2807\/esm.10.05.00535-en"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2007.027334"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/431486"},{"key":"e_1_2_8_8_1","unstructured":"GallottaG GaliL De BonaA et\u00a0al.Acute hepatitis C virus in HIV co\u2010infected men who have sex with men: Milano 1996\u20132007. 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