{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:52:59Z","timestamp":1767707579778},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370602","81300442","81400082"],"award-info":[{"award-number":["81370602","81300442","81400082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK2012573","BK20140219"],"award-info":[{"award-number":["BK2012573","BK20140219"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Injury to liver sinusoidal endothelial cells (<jats:styled-content style=\"fixed-case\">LSEC<\/jats:styled-content>s) is thought to be the initial factor for Hepatic veno\u2010occlusive disease, a severe complication after haematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Endothelial progenitor cells (<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s) have the capacity to differentiate into endothelial cells and play a critical role in vasculogenesis, tissue regeneration and repair. Whether <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s infusion ameliorates <jats:styled-content style=\"fixed-case\">LSEC<\/jats:styled-content>s injury remains unclear. The aim of this study was to evaluate the effects of <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s on liver injury in mice after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice received <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> without or with <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s infusion (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s). Untreated mice were used as control. Liver and whole blood were collected post <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> and used for the analysis of pathology of liver sinusoidal endothelial cells (<jats:styled-content style=\"fixed-case\">LSEC<\/jats:styled-content>s) and hepatocytes, liver ultrastructure, function, level of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and platelet activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severe <jats:styled-content style=\"fixed-case\">LSEC<\/jats:styled-content>s injury, hepatocyte damage, abnormal liver function was observed in <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> group. In addition, increased P\u2010selectin expression and secretion of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 was also found. However, all the above changes were alleviated in <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s at all the time points and normalized at the endpoint. Meanwhile, <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s\u2010induced repair of <jats:styled-content style=\"fixed-case\">LSEC<\/jats:styled-content>s and hepatocytes was totally inhibited by the addition of anti\u2010<jats:styled-content style=\"fixed-case\">VE<\/jats:styled-content>\u2010cadherin antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s infusion ameliorated the damage to <jats:styled-content style=\"fixed-case\">LSEC<\/jats:styled-content>s and hepatocytes as well as reduced secretion of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and inhibited platelet activation after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, leading to improved liver function, suggesting <jats:styled-content style=\"fixed-case\">EPC<\/jats:styled-content>s might be a new therapeutic strategy in the prophylaxis of liver injury after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12849","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T07:59:10Z","timestamp":1429084750000},"page":"2611-2620","source":"Crossref","is-referenced-by-count":20,"title":["Infusion of endothelial progenitor cells ameliorates liver injury in mice after haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"35","author":[{"given":"Jianlin","family":"Qiao","sequence":"first","affiliation":[{"name":"Blood Diseases Institute Xuzhou Medical College Xuzhou 221002 China"},{"name":"Key Laboratory of Bone Marrow Stem Cell Jiangsu Province Xuzhou 221002 China"},{"name":"Department of Hematology The Affiliated Hospital of Xuzhou Medical College Xuzhou 221002 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