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Somatostatin can decrease portal vein pressure (<jats:styled-content style=\"fixed-case\">PVP<\/jats:styled-content>) but simultaneously inhibits liver regeneration. This interesting paradox motivated us to investigate the outcome of <jats:styled-content style=\"fixed-case\">PLF<\/jats:styled-content> in response to somatostatin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats receiving extended partial hepatectomy (90% <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content>) were treated with octreotide, a somatostatin analogue, or placebo. Animal survival, serum parameters and hepatic histology were evaluated. Metabolomic analysis was performed to investigate the effect of octreotide on hepatocyte metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Despite significantly inhibiting early regeneration, octreotide application noticeably improved the hepatic histology, liver function and survival after <jats:styled-content style=\"fixed-case\">PH<\/jats:styled-content> but did not decrease the <jats:styled-content style=\"fixed-case\">PVP<\/jats:styled-content> level. Metabolomic analysis exhibited that octreotide profoundly and exclusively altered the levels of five metabolites that participate in or closely associate with the methionine cycle, a biochemical reaction that uniquely produces S\u2010adenosylmethionine (<jats:styled-content style=\"fixed-case\">SAM<\/jats:styled-content>e), an active methyl residual donor for methyltransferase reactions. Among these metabolites, 5\u2032\u2010methylthioadenosine (<jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content>), a derivate of <jats:styled-content style=\"fixed-case\">SAM<\/jats:styled-content>e, increased three\u2010fold and was found independently improve the hepatic histology and reduce inflammatory cytokines in hepatectomized rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Octreotide exclusively regulates the methionine cycle reaction and augments the <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> level in hepatocytes. <jats:styled-content style=\"fixed-case\">MTA<\/jats:styled-content> prominently protects hepatocytes against shear stress injury and reduces the secondary inflammation, thereby protecting rats from <jats:styled-content style=\"fixed-case\">PLF<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12863","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T06:45:35Z","timestamp":1430894735000},"page":"212-222","source":"Crossref","is-referenced-by-count":23,"title":["Octreotide prevents liver failure through upregulating 5\u2032\u2010methylthioadenosine in extended hepatectomized rats"],"prefix":"10.1111","volume":"36","author":[{"given":"Zhenggui","family":"Du","sequence":"first","affiliation":[{"name":"Laboratory of Pathology West China Hospital Sichuan University Chengdu China"},{"name":"Department of Liver Surgery West China Hospital Sichuan University Chengdu China"},{"name":"Department of Thyroid and Breast Surgery West China Hospital Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology West China Hospital 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