{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:47:09Z","timestamp":1778885229682,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:00:00Z","timestamp":1433721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"DFG","award":["Wi 1502\/5-2"],"award-info":[{"award-number":["Wi 1502\/5-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Vascular hyporeactivity to vasoconstrictors contributes to splanchnic arterial vasodilatation and hemodynamic dysregulation in portal hypertension. Neuropeptide Y (<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>), a sympathetic cotransmitter, has been shown to improve adrenergic vascular contractility in portal hypertensive rats and markedly attenuate hyperdynamic circulation. To further characterize the<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>\u2010effects in portal hypertension, we investigated its role for non\u2010receptor\u2010mediated vasoconstriction in the superior mesenteric artery (<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>) of portal vein ligated (<jats:styled-content style=\"fixed-case\">PVL<\/jats:styled-content>) and sham\u2010operated rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Ex vivo<\/jats:italic><jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>perfusion of<jats:styled-content style=\"fixed-case\">PVL<\/jats:styled-content>and sham rats was used to analyse the effects of<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>on pressure response to non\u2010receptor\u2010mediated vasoconstriction. Dose\u2013response curves to<jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>l (30\u2013300\u00a0mM) were used to bypass G protein\u2010coupled receptor mechanisms. Potential involvement of the cyclooxygenase\u2010pathway was tested by non\u2010selective cyclooxygenase\u2010inhibition using indomethacin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>l\u2010induced vascular contractility but not vascular sensitivity was significantly attenuated in<jats:styled-content style=\"fixed-case\">PVL<\/jats:styled-content>rats as compared with sham rats. Administration of<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>resulted in an augmentation of<jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>l\u2010evoked vascular sensitivity being not different between study groups. However,<jats:styled-content style=\"fixed-case\">KC<\/jats:styled-content>l\u2010induced vascular contractility was markedly more enhanced in<jats:styled-content style=\"fixed-case\">PVL<\/jats:styled-content>rats, thus, vascular response was no more significantly different between<jats:styled-content style=\"fixed-case\">PVL<\/jats:styled-content>and sham rats after addition of<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>. Administration of indomethacin abolished the<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>\u2010induced enhancement of vasoconstriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Receptor\u2010independent vascular contractility is impaired in mesenteric arteries in portal hypertension.<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>improves non\u2010receptor mediated mesenteric vasoconstriction more effective in portal hypertension than in healthy conditions correcting splanchnic vascular hyporesponsiveness. This beneficial vasoactive action of<jats:styled-content style=\"fixed-case\">NPY<\/jats:styled-content>adds to its well known more pronounced effects on adrenergic vasoconstriction in portal hypertension making it a promising therapeutic agent in portal hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12874","type":"journal-article","created":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T12:26:58Z","timestamp":1432297618000},"page":"2556-2563","source":"Crossref","is-referenced-by-count":11,"title":["Neuropeptide Y restores non\u2010receptor\u2010mediated vasoconstrictive action in superior mesenteric arteries in portal hypertension"],"prefix":"10.1111","volume":"35","author":[{"given":"Johannes","family":"Hartl","sequence":"first","affiliation":[{"name":"First Medical Center University Hospital Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU) Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Moleda","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Medical Center Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"M\u00fcller\u2010Schilling","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Medical Center Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiner","family":"Wiest","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery and Medicine Bern University Hospital Inselspital Bern 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