{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:51:24Z","timestamp":1788565884591,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Finnish Pediatric Research Foundation"},{"name":"Sigrid Juselius Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>We aimed to evaluate the value of <jats:styled-content style=\"fixed-case\">AST<\/jats:styled-content> to platelet ratio (<jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content>) and transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>) as predictors of liver histopathology in children with intestinal failure (<jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Altogether 93 liver biopsies from 57 children with parenteral nutrition (<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>) duration \u22653\u00a0months were analysed. <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content> measurement and <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a046) were performed at the time of biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content> was caused by short bowel syndrome in 75% of patients. At the time of liver biopsy, <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> dependent patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a042) were younger with longer <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> duration compared to those weaned off <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a051) (2.2 vs. 7.6\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; 26 vs. 10.5\u00a0months, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043). Elevated transaminase or bilirubin levels were found in 51%, splenomegaly in 26%, and oesophageal varices in 3.5%. Histological fibrosis was present in 61% (Metavir stage F1; 27%, F2; 26%, F3\u20134; 9%), cholestasis in 25% and steatosis in 22% of biopsy specimens. <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> was superior to <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content> in prediction of any liver histopathology (fibrosis, cholestasis or steatosis) with areas under the receiving operating curve (<jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>) of 0.86 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.74\u20130.97) and 0.67 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.58\u20130.78) respectively. For prediction of \u2265F1 and \u2265F2 fibrosis, <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content> values for <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> were 0.78 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.64\u20130.93) and 0.73 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.59\u20130.88), whereas <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content> did not correlate with fibrosis stages. For detection of histological cholestasis, the <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content> was 0.77 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.64\u20130.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content> are promising noninvasive methods for monitoring the development of <jats:styled-content style=\"fixed-case\">IF<\/jats:styled-content>\u2010related liver histopathology. <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> values reflected the degree of fibrosis better while <jats:styled-content style=\"fixed-case\">APRI<\/jats:styled-content> detected histological cholestasis more accurately.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12887","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T08:05:59Z","timestamp":1433923559000},"page":"361-369","source":"Crossref","is-referenced-by-count":37,"title":["Transient elastography and aspartate aminotransferase to platelet ratio predict liver injury in paediatric intestinal failure"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-8391","authenticated-orcid":false,"given":"Maria","family":"Hukkinen","sequence":"first","affiliation":[{"name":"Pediatric Liver and Gut Research Group Children's Hospital Helsinki University Hospital University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reetta","family":"Kivisaari","sequence":"additional","affiliation":[{"name":"HUS Medical Imaging Center Children's Hospital Helsinki University Hospital University of Helsinki Helsinki 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