{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:12:48Z","timestamp":1790691168794,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Hepatitis C virus\u2010related B\u2010cell proliferation is a model of virus\u2010driven autoimmune\/neoplastic disorder leading to mixed cryoglobulinaemia and\/or B\u2010cell non\u2010Hodgkin lymphoma. These lymphomas are often marginal zone lymphomas or diffuse large B\u2010cell lymphomas. Peginterferon\/Ribavirin therapy has proved its crucial role in the cure of these non\u2010Hodgkin lymphomas, but data are lacking concerning new direct anti\u2010viral agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report five cases of Hepatitis C virus\u2010associated B\u2010cell non\u2010Hodgkin lymphoma treated with direct anti\u2010viral agents: two marginal zone lymphomas received direct anti\u2010viral agents alone (one with a leukaemic phase only, one with splenic and deep lymph nodes localizations); one renal marginal zone lymphoma with renal insufficiency received direct anti\u2010viral agents and four rituximab infusions simultaneously; two diffuse large B\u2010cell lymphomas were treated with direct ant\u2010viral agents following chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sustained virological response was obtained in all patients, and complete remission of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> was noted 6\u00a0months after cessation of any treatment except for one patient with a persistent small leukaemic phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Direct anti\u2010viral agents might be proposed as a first\u2010line treatment in marginal zone lymphomas in the case of no life\u2010threatening complications with the precaution of a long\u2010term follow\u2010up. In the setting of diffuse large B\u2010cell lymphomas, well\u2010tolerated direct anti\u2010viral agents could potentially be introduced very early not only to prevent relapse of these lymphomas but also to limit the liver toxicity of chemotherapy and rituximab by preventing outbreaks of viral load. New observations and trials should support these assumptions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12897","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T05:12:02Z","timestamp":1435036322000},"page":"2222-2227","source":"Crossref","is-referenced-by-count":58,"title":["<scp>HCV<\/scp>\u2010associated <scp>B<\/scp>\u2010cell non\u2010<scp>H<\/scp>odgkin lymphomas and new direct antiviral agents"],"prefix":"10.1111","volume":"35","author":[{"given":"Paul","family":"Carrier","sequence":"first","affiliation":[{"name":"Service d'H\u00e9pato\u2010gastroent\u00e9rologie CHU Limoges Limoges France"},{"name":"U850 INSERM Univ. Limoges CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Jaccard","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Jacques","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010gastroent\u00e9rologie CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Tabouret","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010gastroent\u00e9rologie CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyne","family":"Debette\u2010Gratien","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato\u2010gastroent\u00e9rologie CHU Limoges Limoges France"},{"name":"U850 INSERM Univ. Limoges CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Abraham","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Clinique CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mesturoux","sequence":"additional","affiliation":[{"name":"Service d'Anatomopathologie CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Marquet","sequence":"additional","affiliation":[{"name":"U850 INSERM Univ. Limoges CHU Limoges Limoges France"},{"name":"Service de Pharmacologie CHU Limoges Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Alain","sequence":"additional","affiliation":[{"name":"U850 INSERM Univ. Limoges CHU Limoges Limoges France"},{"name":"U1092 INSERM Univ. 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