{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:04:53Z","timestamp":1793156693192,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,9]],"date-time":"2015-09-09T00:00:00Z","timestamp":1441756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["20130023"],"award-info":[{"award-number":["20130023"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","award":["20130156"],"award-info":[{"award-number":["20130156"]}],"id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n \n Non\u2010alcoholic fatty liver disease (\n NAFLD<\/jats:styled-content>\n ) is considered the most common liver disease in the world, but little is known about its potential association with pregnancy outcomes. We aimed to investigate pregnancy outcomes in\n NAFLD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The Swedish Medical Birth Register (\n MBR<\/jats:styled-content>\n ) was used to identify births between 1992 and 2011 (\n N<\/jats:italic>\n \u00a0=\u00a01\u00a0960\u00a0416). By linkage with the National Patient Register, we identified women with a diagnosis of\n NAFLD<\/jats:styled-content>\n . The\n MBR<\/jats:styled-content>\n was then used to identify outcomes: gestational diabetes, pre\u2010eclampsia, Caesarean section, Apgar score <7 at 5\u00a0min, preterm birth (<37\u00a0weeks), low birth weight (<2500\u00a0g), infants born small for gestational age and congenital malformations. As controls, we used women with no diagnosis for\n NAFLD<\/jats:styled-content>\n divided into two groups; with and without polycystic ovary syndrome (\n PCOS<\/jats:styled-content>\n ). Poisson regression was used to estimate relative risks (\n RR<\/jats:styled-content>\n s) adjusted for maternal age, smoking status and body mass index at early pregnancy, parity and prepregnancy diabetes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We identified 110 pregnancies in women with\n NAFLD<\/jats:styled-content>\n . Using women without a diagnosis of\n NAFLD<\/jats:styled-content>\n or\n PCOS<\/jats:styled-content>\n as controls;\n NAFLD<\/jats:styled-content>\n was associated with gestational diabetes [adjusted\n RR<\/jats:styled-content>\n s 2.78; 95% confidence interval (\n CI<\/jats:styled-content>\n ): 1.25\u20136.15], pre\u2010eclampsia (\n aRR<\/jats:styled-content>\n 1.95; 95%\n CI<\/jats:styled-content>\n 1.03\u20133.70), Caesarean section (\n aRR<\/jats:styled-content>\n 1.52; 95%\n CI<\/jats:styled-content>\n 1.19\u20131.94), preterm birth (\n aRR<\/jats:styled-content>\n 2.50; 95%\n CI<\/jats:styled-content>\n 1.38\u20134.55) and with low birth weight (\n aRR<\/jats:styled-content>\n 2.40; 95%\n CI<\/jats:styled-content>\n 1.21\u20134.78).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Women with a diagnosis of\n NAFLD<\/jats:styled-content>\n prior to giving birth have increased risks for adverse pregnancy outcome independently of body mass index and diabetes, and should be carefully monitored during antenatal care.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.12902","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T10:02:13Z","timestamp":1435226533000},"page":"268-274","source":"Crossref","is-referenced-by-count":112,"title":["Adverse outcomes of pregnancy in women with non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"36","author":[{"given":"Hannes","family":"Hagstr\u00f6m","sequence":"first","affiliation":[{"name":"Center for Digestive Diseases Unit of Hepatology Karolinska University Hospital Institute of Medicine Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0012-1211","authenticated-orcid":false,"given":"Jonas","family":"H\u00f6ijer","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"},{"name":"Department of Paediatrics \u00d6rebro University Hospital \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bottai","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Ekbom","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Karolinska University Hospital and Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Hultcrantz","sequence":"additional","affiliation":[{"name":"Center for Digestive Diseases Unit of Hepatology Karolinska University Hospital Institute of Medicine Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"Stephansson","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Karolinska University Hospital and Institutet Stockholm Sweden"},{"name":"Department of Women's and Children's Health Division of Obstetrics and Gynaecology Karolinska University Hospital and Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Stokkeland","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Department of Medicine Karolinska University Hospital and Institutet Stockholm Sweden"},{"name":"Department of Medicine Visby Hospital Visby 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