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We intend to compare the effects of increasing doses of clonidine (\u03b12\u2010agonist) vs. midodrine (\u03b11\u2010agonist) in advanced cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Renal function, mean arterial pressure (MAP), and hormonal status were measured in rats with ascitic cirrhosis due to 13\u2010week CCl<jats:sub>4<\/jats:sub>administration (groups G1\u2010G5), in control rats (Gc), and in rats with ascitic cirrhosis untreated (G6) or treated with daily diuretics (0.5\u00a0mg\/kg furosemide plus 2\u00a0mg\/kg K<jats:sup>+<\/jats:sup>\u2010canrenoate during the 11<jats:sup>th<\/jats:sup>\u201313<jats:sup>th<\/jats:sup>weeks of CCl<jats:sub>4<\/jats:sub>) (G7). G1\u2013G5 cirrhotic rats received daily, during the 11th\u201313th CCl<jats:sub>4<\/jats:sub>weeks: clonidine 0.3\u00a0\u03bcg only (G1), diuretics + clonidine 0.2 (G2), 0.5 (G3) or 1\u00a0\u03bcg (G4), and diuretics + midodrine 1\u00a0mg\/kg b.w. (G5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cirrhotic rats in G1 or G2 had higher glomerular filtration rate, renal plasma flow and natriuresis than cirrhotic rats treated with diuretics (G7) (all<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The addition of clonidine 0.2\u00a0\u03bcg to diuretics (G2 vs. G7) reduced serum norepinephrine (169\u00a0\u00b1\u00a071\u00a0ng\/L vs. 523\u00a0\u00b1\u00a088\u00a0ng\/L) and plasma renin activity (12\u00a0\u00b1\u00a03\u00a0ng\/ml\/h vs. 25\u00a0\u00b1\u00a05\u00a0ng\/ml\/h) (all<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Midodrine did not improve the renal performance in ascitic rats treated with diuretics. In comparison to absolute cirrhotic controls (G6),<jats:styled-content style=\"fixed-case\">MAP<\/jats:styled-content>was lower in G4 and higher in G5 (all<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010dose \u03b12\u2010agonists improve natriuresis and reduce<jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>function and hyper\u2010aldosteronism without affecting arterial pressure in experimental ascitic cirrhosis treated with diuretics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12905","type":"journal-article","created":{"date-parts":[[2015,6,30]],"date-time":"2015-06-30T08:01:03Z","timestamp":1435651263000},"page":"205-211","source":"Crossref","is-referenced-by-count":4,"title":["Dose\u2010dependency of clonidine's effects in ascitic cirrhotic rats: comparison with \u03b11\u2010adrenergic agonist 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