{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T15:43:25Z","timestamp":1771947805149,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"publisher","award":["12\/15"],"award-info":[{"award-number":["12\/15"]}],"id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Different mechanisms including portal hypertension and hypersplenism have been involved in the development of thrombocytopenia in cirrhosis. However, the relative contribution of each one is unknown. The aim was to evaluate simultaneously different mechanisms that determine platelet count in cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study including cirrhotics (<jats:italic>n<\/jats:italic>\u00a0=\u00a0120) with hepatic venous pressure gradient (<jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>) measurement. Samples were obtained from peripheral (P) veins to evaluate thrombopoietin (<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>), stem cell factor, hepatocyte growth factor (<jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>), tumour necrosis factor, interleukin\u2010(IL6) and (IL11) and from hepatic (H) veins to evaluate <jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>. A subgroup (<jats:italic>n<\/jats:italic>\u00a0=\u00a072) had spleen volume estimation. H and P\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> were also measured in non\u2010cirrhotic patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients (Child A: 55, B: 43, C: 22) had a median platelet count of 81\u00a0000\/mm<jats:sup>3<\/jats:sup> (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 60\u00a0500, 110\u00a0750), which correlated with spleen volume (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.38, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Platelets were associated also to <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.47, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) and P\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.31, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.050) only in compensated patients. H\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> decreased, and the proportion of patients with P\u2010TPO\u00a0&gt;\u00a0H\u2010TPO increased, with the presence and the severity of liver disease. H\u2010TPO was correlated with liver function (bilirubin <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.350, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and international normalized ratio <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.227, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011). Patients with H\u2010TPO\u00a0&lt;\u00a0P\u2010TPO had higher levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201011 and <jats:styled-content style=\"fixed-case\">HGF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platelet count in cirrhosis is associated mainly to spleen volume, although portal hypertension as estimated by <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> and liver function plays a significant role in compensated patients. H\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> and the proportion of patients with P\u2010TPO\u00a0&gt;\u00a0H\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> were associated to the presence and severity of liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12908","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T10:35:50Z","timestamp":1435833350000},"page":"232-239","source":"Crossref","is-referenced-by-count":13,"title":["Determinants of platelet count are different in patients with compensated and decompensated cirrhosis"],"prefix":"10.1111","volume":"36","author":[{"given":"Raquel","family":"Latorre","sequence":"first","affiliation":[{"name":"Department of Digestive Diseases Liver Unit Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"CIBERehd Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Vaquero","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases Liver Unit Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"CIBERehd Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Digestive Diseases Liver Unit Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"},{"name":"CIBERehd Hospital General Universitario Gregorio Mara\u00f1\u00f3n Madrid 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