{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T07:21:24Z","timestamp":1780557684981,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T00:00:00Z","timestamp":1441497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Aims<\/jats:title><jats:p>Endoscopic screening for high\u2010risk gastro\u2010oesophageal varices (<jats:styled-content style=\"fixed-case\">GOV<\/jats:styled-content>) is recommended for compensated cirrhotic patients with transient elastography identifying increasing numbers of patients with cirrhosis without portal hypertension. Using liver stiffness measurement (<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content>) \u00b1 platelet count, the aim was to develop a simple clinical rule to exclude the presence of high\u2010risk <jats:styled-content style=\"fixed-case\">GOV<\/jats:styled-content> in patients with Child\u2013Pugh A cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 71 patients with Child\u2013Pugh A cirrhosis diagnosed by transient elastography (<jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> &gt;13.6\u00a0<jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a) who underwent screening gastroscopy was conducted. A predictive model using <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> \u00b1 platelet count was assessed to exclude the presence of high\u2010risk <jats:styled-content style=\"fixed-case\">GOV<\/jats:styled-content> (diameter &gt;5\u00a0mm and\/or the presence of high\u2010risk stigmata) and validated using a second cohort of 200 patients from two independent centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010risk <jats:styled-content style=\"fixed-case\">GOV<\/jats:styled-content> were present in 10 (15%) and 16 (8%) of the training and validation cohorts, respectively, which was associated with <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> and Pl count (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). A combined model based on <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> and Pl count was more accurate for excluding the presence of high\u2010risk <jats:styled-content style=\"fixed-case\">GOV<\/jats:styled-content> than either alone (training cohort <jats:styled-content style=\"fixed-case\">AUROC<\/jats:styled-content>: 0.87 [0.77\u20130.96] vs. 0.78 [0.65\u20130.92] for <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> and 0.71 [0.52\u20130.90] for platelets) with the combination of <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> \u226425\u00a0kPa and Pl \u2265100 having a <jats:styled-content style=\"fixed-case\">NPV<\/jats:styled-content> of 100% in both the training and validation cohorts. A total of 107 (39%) patients meet this criterion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of <jats:styled-content style=\"fixed-case\">LSM<\/jats:styled-content> \u226425 <jats:styled-content style=\"fixed-case\">kP<\/jats:styled-content>a and Pl \u2265100 can be used in clinical practice to exclude the presence of high\u2010risk <jats:styled-content style=\"fixed-case\">GOV<\/jats:styled-content> in patients with Child\u2013Pugh A cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12916","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T09:41:09Z","timestamp":1437817269000},"page":"240-245","source":"Crossref","is-referenced-by-count":67,"title":["Liver stiffness plus platelet count can be used to exclude high\u2010risk oesophageal varices"],"prefix":"10.1111","volume":"36","author":[{"given":"Nik S.","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Iser","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avelyn","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Luiz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Y. C.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Fulforth","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinta","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marno","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally J.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul V.","family":"Desmond","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart K.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lubel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Eastern Health Melbourne VIC Australia"},{"name":"Eastern Health Clinical School Monash University Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kemp","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Alfred Hospital Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital Melbourne and the University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,6]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1081","article-title":"Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension. 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