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While <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>9 is associated with survival in patients receiving transjugular intrahepatic portosystemic shunt (<jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>), the role of <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11 in severe portal hypertension remains unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11\u2010levels were measured in 136 patients with liver diseases, and 63 healthy controls. In further 47 cirrhotic patients receiving <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CXCL<\/jats:styled-content>11 levels were measured in portal and hepatic veins at <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> insertion by cytometric bead array. <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11\u2010levels were measured in 23 patients in cubital vein and right atrium, whereas in 24 patients in portal and hepatic blood at an invasive reevaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11\u2010levels were increased with the severity of liver fibrosis. <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11\u2010levels from portal, hepatic and cubital veins and right atrium showed a highly significant correlation among each other in these patients. Furthermore, levels of <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11 from the right atrium were significantly higher than those from cubital vein. Interestingly, patients with alcoholic cirrhosis had significantly lower <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11\u2010levels, than other aetiologies of cirrhosis. After <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CXCL<\/jats:styled-content>11 levels correlated with the degree of portal pressure and patients with higher <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11\u2010levels in portal and hepatic veins showed higher mortality. Multivariate analysis revealed hepatic <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11\u2010levels before <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>, creatinine and age as independent predictors for survival in <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> patients, whereas <jats:styled-content style=\"fixed-case\">MELD<\/jats:styled-content> score and low portal <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11\u2010levels after <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> predicted long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11 levels are mainly increased in patients with non\u2010alcoholic cirrhosis and high portal pressure. Moreover, levels of <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>11 might predict long\u2010time survival of cirrhotic patients bearing <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12922","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T15:09:24Z","timestamp":1437836964000},"page":"386-394","source":"Crossref","is-referenced-by-count":36,"title":["Chemokine (C\u2010X\u2010C motif) ligand 11 levels predict survival in cirrhotic patients with transjugular intrahepatic portosystemic shunt"],"prefix":"10.1111","volume":"36","author":[{"given":"Marie\u2010Luise","family":"Berres","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III RTWH Aachen Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I 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