{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:22:57Z","timestamp":1790486577351,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Yonsei University Future-leading Research Initiative of 2014"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>The need for further histological subclassification of cirrhosis has been increasingly recognized because of the heterogeneity of severity within cirrhosis. We sought to identify evidence in the literature regarding the histological subclassification of cirrhosis using the Laennec stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review and meta\u2010analysis by searching databases, including <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> EMBASE<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">COCHRANE<\/jats:styled-content> library, for relevant studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 208 studies identified, 16 were eligible according to the inclusion criteria. With higher grades of the Laennec stage, clinical stages of cirrhosis and Child\u2013Pugh scores\/Model for end\u2010stage liver disease scores increased (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Higher Laennec stages were statistically associated with the development of liver\u2010related events, such as liver\u2010related death, liver cancer progression and variceal haemorrhage, as well as higher hepatic venous pressure gradients and higher liver stiffness values (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Two open\u2010labelled studies showed the usefulness of the Laennec system with regard to the evaluation of whether antifibrotic treatments were effective. The mean kappa value was 0.81 (range 0.61\u20130.87) for inter\u2010observer agreement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on this systematic review and meta\u2010analysis, histological subclassification of cirrhosis using the Laennec system is useful to better predict prognosis and complications of portal hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12923","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T15:35:23Z","timestamp":1437838523000},"page":"847-855","source":"Crossref","is-referenced-by-count":21,"title":["The need for histological subclassification of cirrhosis: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"given":"Gaeun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nursing Research Institute for Nursing Science Keimyung University College of Nursing Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Liver unit University of Calgary Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Koo","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Korea"},{"name":"Cell Therapy and Tissue Engineering Center Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Zoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Ok","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hwan","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Radiology Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mee Yon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University Wonju College of Medicine Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25752"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2013.19.4.389"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_8_5_1","first-page":"407","article-title":"The Laennec grading system for assessment of hepatic fibrosis: validation by correlation with wedged hepatic vein pressure and clinical features","volume":"32","author":"Kutami R","year":"2000","journal-title":"Hepatology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2014.20.2.137"},{"key":"e_1_2_8_7_1","unstructured":"HigginsJ GreenSCochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration. Available athttp:\/\/handbook.cochrane.org\/Accessed 30 September 2014."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_8_9_1","unstructured":"Scottish Intercollegiate Guidelines Network.Methodology checklist 2: controlled trials. Available athttp:\/\/www.sign.ac.uk\/methodology\/checklists.htmlAccessed 30 September 2014."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.02.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12475"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032233"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.04.029"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12070"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02521.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02774.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12218"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.023"},{"key":"e_1_2_8_20_1","first-page":"495","article-title":"Staging cirrhosis to improve the long\u2010term outcomes of liver resection for hepatocellular carcinoma","volume":"16","author":"Huang ZY","year":"2014","journal-title":"HPB"},{"key":"e_1_2_8_21_1","first-page":"1079","article-title":"Liver stiffness measurement is useful in discrimination of the severity of cirrhosis in histological grade according to Laennec fibrosis scoring system","volume":"52","author":"Kim MY","year":"2010","journal-title":"Hepatology"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(12)60092-0"},{"key":"e_1_2_8_23_1","first-page":"1264","article-title":"Histological sub\u2010classification of cirrhosis using Laennec staging system is useful for the stratification of prognosis in patients with cirrhosis","volume":"54","author":"Oh HJ","year":"2011","journal-title":"Hepatology"},{"key":"e_1_2_8_24_1","first-page":"936","article-title":"Cirrhosis histology and Laennec fibrosis scoring correlate with high portal pressure","volume":"54","author":"Rastogi A","year":"2011","journal-title":"Hepatology"},{"key":"e_1_2_8_25_1","first-page":"432","article-title":"Histological sub classification of cirrhosis with Laennec staging system and correlation with clinical findings","volume":"94","author":"Yilmaz F","year":"2014","journal-title":"Lab Invest"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12923","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.12923","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.12923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:33:47Z","timestamp":1695562427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.12923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,28]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/liv.12923"],"URL":"https:\/\/doi.org\/10.1111\/liv.12923","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,28]]}}}