{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:16:47Z","timestamp":1776194207059,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T00:00:00Z","timestamp":1441497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Few information is available regarding atrial fibrillation in cirrhotic patients. The aim of this study was to investigate the occurrence and clinical impact of atrial fibrillation in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three hundred and thirty\u2010five cirrhotic patients (219 males; mean age 65\u00a0\u00b1\u00a010.85\u00a0years; 196 Child\u2013Pugh class A, 104 class B and 35 class C) were consecutively analysed and followed up for 24\u00a0months. Electrocardiograms were available for all patients before starting the study, at basaltime and during the follow\u2010up. Echocardiography was performed in individuals with atrial fibrillation and in 100 randomly chosen patients without it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Atrial fibrillation was observed in 21\/335 cirrhotics (mean age 75\u00a0\u00b1\u00a07\u00a0years, 13 male), six of whom had permanent and 15 had paroxysmal atrial fibrillation. At univariate analysis, atrial fibrillation significantly correlated with older age, history of coronary heart disease, Child\u2013Pugh score, serum albumin, hepatic encephalopathy, treatment with furosemide, <jats:styled-content style=\"fixed-case\">QT<\/jats:styled-content>c prolongation, atrial section areas, increased <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content>s and thickness of interventricular septum. Age [odd ratio 1.12, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (1.05\u20131.2), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001], history of coronary heart disease [odd ratio 4.93, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (1.04\u201323.54), <jats:italic>P\u00a0<\/jats:italic>=\u00a00.04] and <jats:styled-content style=\"fixed-case\">PAP<\/jats:styled-content>s [odd ratio 1.12, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (1.02\u20131.2), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01] maintained statistical significance at multivariate analysis. Fifty\u2010one of the 335 patients died during the follow\u2010up. At Cox regression analysis, advanced Child\u2013Pugh score [hazard ratio 1.546, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (1.357\u20131.762), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.037] and increased heart rate [hazard ratio 1.117, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> (1.021\u20131.223), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016] were significantly associated with mortality which was independent of atrial fibrillation occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cirrhosis is not a predisposing factor of atrial fibrillation, which in turn has no impact on mortality in cirrhotic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12928","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T11:49:02Z","timestamp":1438602542000},"page":"395-400","source":"Crossref","is-referenced-by-count":16,"title":["Atrial fibrillation in patients with 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