{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:06:35Z","timestamp":1777111595310,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,5]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>The role of transjugular intrahepatic portosystemic shunt (TIPS<\/jats:styled-content>) for the secondary prophylaxis of variceal bleeding in cirrhotic patients with portal vein thrombosis (PVT<\/jats:styled-content>) remains obscure. This prospective cohort study aimed to assess the risk factors associated with TIPS<\/jats:styled-content> technical success, outcome and prognosis in cirrhotic patients with PVT<\/jats:styled-content> and a history of variceal bleeding.<\/jats:p><\/jats:sec>Methods<\/jats:title>Between M<\/jats:styled-content>ay 2009 and A<\/jats:styled-content>pril 2011, 51 cirrhotic patients with PVT<\/jats:styled-content> who attempted TIPS<\/jats:styled-content> procedures for the prevention of variceal rebleeding were enrolled.<\/jats:p><\/jats:sec>Results<\/jats:title>TIPS<\/jats:styled-content> success rate was 84% (43\/51). An increased degree of thrombosis within the portal trunk and portal vein branches was inversely associated with TIPS<\/jats:styled-content> success. Median follow\u2010up time was 40.07\u00a0months (range: 0.02\u201356.87). The cumulative risk of rebleeding was significantly different between TIPS<\/jats:styled-content> success and failure group (P<\/jats:italic>\u00a0=\u00a00.002). The univariate analysis also demonstrated that TIPS<\/jats:styled-content> failure was the only significant predictor associated with rebleeding (hazard ratio [HR<\/jats:styled-content>]\u00a0=\u00a04.174, 95% confidence interval [CI<\/jats:styled-content>]: 1.558\u201311.186). In TIPS<\/jats:styled-content> success group, the cumulative rates free of shunt dysfunction at the 6th and 12th month were 79% and 76% respectively. Absence of total superior mesenteric vein (SMV<\/jats:styled-content>) thrombosis was the only independent predictor (HR<\/jats:styled-content>\u00a0=\u00a00.189, 95% CI<\/jats:styled-content>: 0.047\u20130.755). In TIPS<\/jats:styled-content> success group, the 1\u2010 and 3\u2010year cumulative survival rates were 77% and 62% respectively. Albumin level was the only independent predictor (HR<\/jats:styled-content>\u00a0=\u00a00.877, 95% CI<\/jats:styled-content>: 0.779\u20130.986).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Successful TIPS<\/jats:styled-content> insertions could effectively prevent from rebleeding in cirrhotic patients with PVT<\/jats:styled-content> and variceal bleeding. Degree of PVT<\/jats:styled-content> and SMV<\/jats:styled-content> thrombosis was associated with TIPS<\/jats:styled-content> failure and shunt dysfunction respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12929","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T11:53:21Z","timestamp":1438602801000},"page":"667-676","source":"Crossref","is-referenced-by-count":61,"title":["Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with variceal bleeding in liver cirrhosis: outcomes and predictors in a prospective cohort study"],"prefix":"10.1111","volume":"36","author":[{"given":"Xingshun","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Liver Diseases and Digestive Interventional Radiology Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an 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