{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T07:01:49Z","timestamp":1781420509644,"version":"3.54.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T00:00:00Z","timestamp":1441497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"PMU-Forschungsf\u00f6rderungsfonds","award":["E-13\/17\/086-AIG"],"award-info":[{"award-number":["E-13\/17\/086-AIG"]}]},{"name":"Spar Austria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Liver biopsy (<jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>) is performed if non\u2010invasive work\u2010up of liver disease is inconclusive. The examination of liver tissue occasionally reveals normal histology. Long\u2010term follow\u2010up of such patients has not been performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified a total 70 subjects from our <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content> database with elevated liver tests and normal liver histology after a mean of 90.5\u00a0\u00b1\u00a052.3 (range 15\u2013216) months and conducted reassessment of medical history, physical examination, laboratory testing, ultrasound, transient elastography and <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content> if indicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At follow\u2010up examination, 15 (7 females (f)\/8 males (m); 21.4%) subjects had normal liver tests and no further evidence of liver disease. A subset of 37 (29 f\/8 m; 52.9%) subjects had persistently elevated liver tests without evidence indicating progressive liver disease but the cause thereof remained unexplained also at the follow\u2010up visit. Three (0 f\/3 m; 4.3%) subjects had consumed excessive alcohol with indicators of alcoholic liver disease. Eleven subjects (4 f\/7 m; 15.7%) had developed steatosis on ultrasound examination along with weight gain and\/or biochemical features of the metabolic syndrome. In addition, three (2 f\/1 m) patients developed autoimmune hepatitis, one female presented with primary biliary cirrhosis. One male was diagnosed with cholangiocellular carcinoma 3\u00a0months after the initial evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The clinical course of most patients was benign, but in approximately 20% of the subjects a liver disease developed. Particular attention should be given to autoimmune liver diseases in subjects with positive autoantibodies. In addition, lifestyle factors such as weight gain and alcohol consumption were associated with the manifestation of liver diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12935","type":"journal-article","created":{"date-parts":[[2015,8,10]],"date-time":"2015-08-10T09:04:07Z","timestamp":1439197447000},"page":"119-125","source":"Crossref","is-referenced-by-count":13,"title":["Natural course of subjects with elevated liver tests and normal liver histology"],"prefix":"10.1111","volume":"36","author":[{"given":"Michael","family":"Strasser","sequence":"first","affiliation":[{"name":"First Department of Medicine Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Stadlmayr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Oberndorf Hospital Oberndorf Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Haufe","sequence":"additional","affiliation":[{"name":"Department of Pathology Paracelsus Medical University Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Stickel","sequence":"additional","affiliation":[{"name":"Hepatology Unit Clinic Beau\u2010Site, Bern and Department of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ferenci","sequence":"additional","affiliation":[{"name":"Third Department of Medicine, Gastroenterology and Hepatology Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Patsch","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Paracelsus Medical University Salzburg 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