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We reviewed PubMed\/<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>through March 2015. We developed a<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>search strategy using PubMed medical subject heading terms chronic liver injury, hepatotoxicity, drug\u2010induced liver injury, cirrhosis and chronic liver disease. We reviewed the reference list of included articles to identify articles missed in the database search. Chronic liver injury from drugs is more common than once thought with prevalence as high as 18% based on large national registries. Patients with cholestatic injury, age \u226465\u00a0years, and a long latency period (&gt;365\u00a0days) are at increased risk. Of the most common drugs associated with drug\u2010induced liver injury, antibiotics (amoxicillin\u2010clavulanic acid, trimethoprim\u2010sulfamethoxazole, azithromycin) are most likely to cause chronic injury. The presence of autoantibodies is common with chronic<jats:styled-content style=\"fixed-case\">DILI<\/jats:styled-content>, however, it is not diagnostic nor is it specific to autoimmune\u2010like drug\u2010induced liver injury. Immunosuppressive therapy may be necessary for individual cases of autoimmune\u2010like drug\u2010induced liver injury where cessation of the drug alone does not result in resolution of injury, however, the lowest dose should be used for the shortest duration with careful attention to the development of side effects. The effectiveness of treament of cholestatic liver injury with corticosteroids or ursodiol remains unclear. Cases of drug\u2010induced fatty liver, nodular regenerative hyperplasia and peliosis hepatitis are less common subtypes of chronic drug\u2010induced liver injury that deserve special consideration. A high degree of clinical suspicion is required for the diagnosis of chronic drug\u2010induced liver injury and should be suspected in any patient with liver associated enzyme abnormalities that persist out past 6\u00a0months of initial presentation. Treatment with drug removal and\/or immunosuppressive therapy appears to be effective for the majority of cases. More study into pharmacogenomics and personalized medicine may aid in predicting which patients will go on to develop chronic drug\u2010induced liver injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12958","type":"journal-article","created":{"date-parts":[[2015,9,8]],"date-time":"2015-09-08T10:55:03Z","timestamp":1441709703000},"page":"2343-2353","source":"Crossref","is-referenced-by-count":83,"title":["Chronic liver injury induced by drugs: a systematic review"],"prefix":"10.1111","volume":"35","author":[{"given":"Jonathan G.","family":"Stine","sequence":"first","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Department of Medicine University of Virginia Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naga","family":"Chalasani","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology Department of Medicine Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510023846"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.09.011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2011.577415"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.131"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.006"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21424"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.58"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23588"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24481"},{"key":"e_1_2_7_12_1","first-page":"1456","article-title":"Drug\u2010induced vanishing bile duct syndrome: response to ursodiol","volume":"91","author":"O'Brien CB","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)82330-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i22.3487"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2007.11.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1375960"},{"key":"e_1_2_7_17_1","first-page":"405","article-title":"Peliosis hepatis. 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