{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:58:08Z","timestamp":1790247488731,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nodular regenerative hyperplasia (<jats:styled-content style=\"fixed-case\">NRH<\/jats:styled-content>) is a rare histological disorder associated with a wide variety of systemic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed (i) to report the prevalence of <jats:styled-content style=\"fixed-case\">NRH<\/jats:styled-content> in a database of liver biopsies (<jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s) and the frequency of portal hypertension (<jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content>) at diagnosis, and (ii) to investigate whether associated diseases and\/or specific histological lesions, including abnormalities of the microvasculature, were related to <jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a histological diagnosis of <jats:styled-content style=\"fixed-case\">NRH<\/jats:styled-content>, referred by seven clinical departments, were retrospectively selected. Clinical, biological, radiological, haemodynamic and endoscopic data at diagnosis were recorded. <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s were reassessed for microvascular abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NRH<\/jats:styled-content> was diagnosed in 4.4% of <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s (<jats:italic>n<\/jats:italic> = 159, male: 52%, mean age: 54). Among patients referred for unexplained liver enzyme abnormalities, 15% had <jats:styled-content style=\"fixed-case\">NRH<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content> was present at diagnosis in 45 patients (38%), including 13 with portal thrombosis; 65% of patients had an associated disorder. Obliteration of portal vein branches, observed in the <jats:styled-content style=\"fixed-case\">LB<\/jats:styled-content>s of 17 patients (11%), was significantly associated with <jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.02). Periportal angiomatosis, observed in 101 patients (63%), was associated with the absence of <jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 10<jats:sup>\u22124<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggest that <jats:styled-content style=\"fixed-case\">NRH<\/jats:styled-content> is a frequent histological lesion in the setting of unexplained liver enzyme abnormalities. <jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content> is present at the time of diagnosis in 1\/3 of patients regardless of the presence of associated disease. The frequency of periportal angiomatosis in <jats:styled-content style=\"fixed-case\">NRH<\/jats:styled-content> without obliteration of portal vein branches, and its association with the absence of <jats:styled-content style=\"fixed-case\">PHT<\/jats:styled-content> suggest that obstructive portal venopathy would not represent the most frequent mechanism involved in <jats:styled-content style=\"fixed-case\">NRH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12974","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T21:09:36Z","timestamp":1443474576000},"page":"1059-1066","source":"Crossref","is-referenced-by-count":45,"title":["Prevalence and clinical significance of nodular regenerative hyperplasia in liver biopsies"],"prefix":"10.1111","volume":"36","author":[{"given":"Sandrine","family":"Barge","sequence":"first","affiliation":[{"name":"Service d'H\u00e9pato\u2010Gastro\u2010ent\u00e9rologie Groupe hospitalier 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