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Lifestyle modifications are effective in the treatment of\n                    <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                    ; however, the long\u2010term compliance is low. Therefore, several pharmacological treatments have been proposed but none has shown significant efficacy or long\u2010term safety. Natural polyphenols are a heterogeneous class of polyphenolic compounds contained in vegetables, which are being proposed for the treatment of different metabolic disorders. Although the beneficial effect of these compounds has traditionally related to their antioxidant properties, they also exert several beneficial effects on hepatic and extra\u2010hepatic glucose and lipid homeostasis. Furthermore, natural polyphenols exert antifibrogenic and antitumoural effects in animal models, which appear relevant from a clinical point of view because of the association of\n                    <jats:styled-content style=\"fixed-case\">NASH<\/jats:styled-content>\n                    with cirrhosis and hepatocellular carcinoma. Several polyphenols, such anthocyanins, curcumin and resveratrol and those present in coffee, tea, soy are available in the diet and their consumption can be proposed as part of a healthy diet for the treatment of\n                    <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                    . Other phenolic compounds, such as silymarin, are commonly consumed worldwide as nutraceuticals or food supplements. Natural antioxidants are reported to have beneficial effects in preclinical models of\n                    <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                    and in pilot clinical trials, and thus need clinical evaluation. In this review, we summarize the existing evidence regarding the potential role of natural antioxidants in the treatment of\n                    <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                    and examine possible future clinical applications.\n                  <\/jats:p>","DOI":"10.1111\/liv.12975","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T11:32:45Z","timestamp":1444044765000},"page":"5-20","source":"Crossref","is-referenced-by-count":220,"title":["Natural antioxidants for non\u2010alcoholic fatty liver disease: molecular targets and clinical perspectives"],"prefix":"10.1111","volume":"36","author":[{"given":"Federico","family":"Salomone","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Ospedale di Acireale Azienda Sanitaria Provinciale di Catania Catania 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