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The aim was to evaluate the association between aortic stiffness, a preclinical <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content> marker, with advanced liver fibrosis identified by transient elastography (<jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>) in T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> outpatients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This longitudinal study included 291 T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> detected by ultrasonography, who had two carotid\u2010femoral pulse wave velocity (cf\u2010<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>) measurements and a <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content> examination (Fibroscan<jats:sup>\u00ae<\/jats:sup>) performed over a median follow\u2010up of 7 years. Advanced liver fibrosis (corresponding to \u2265 F3 stage) was considered as median values &gt;7.9 kPa (M probe) or &gt;7.2 kPa (<jats:styled-content style=\"fixed-case\">XL<\/jats:styled-content> probe). Increased aortic stiffness was defined as cf\u2010<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> &gt;10 m\/s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty patients (27.5%) had advanced liver fibrosis. Overall, there was an increase in cf\u2010<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> of 0.1 m\/s\/year (1% per year). Both a high aortic stiffness at the 2nd cf\u2010<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> examination [odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>): 3.0; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.3\u20137.2; <jats:italic>P<\/jats:italic> = 0.011] and a serial increase in aortic stiffness (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2.1; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.0\u20134.3; <jats:italic>P<\/jats:italic> = 0.046) were associated with increased odds of having advanced liver fibrosis. Patients who presented either an increase in aortic stiffness or persisted with high values had significantly higher mean liver stiffness than those who either decreased aortic stiffness or persisted with normal cf\u2010<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content> values (mean difference: 2.1 kPa, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.5\u20133.7 kPa, <jats:italic>P<\/jats:italic> = 0.012), after adjustments for anthropometric\u2010demographic and clinical laboratory covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>, a high or increasing aortic stiffness predicted development of advanced liver fibrosis on <jats:styled-content style=\"fixed-case\">TE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.12994","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T14:10:53Z","timestamp":1446041453000},"page":"977-985","source":"Crossref","is-referenced-by-count":27,"title":["Increasing aortic stiffness is predictive of advanced liver fibrosis in patients with type 2 diabetes: the Rio\u2010T2<scp>DM<\/scp> cohort study"],"prefix":"10.1111","volume":"36","author":[{"given":"Nathalie C.","family":"Leite","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Medical School and University Hospital Clementino Fraga Filho Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane A.","family":"Villela\u2010Nogueira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical School and University Hospital Clementino Fraga Filho Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel T.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Medical School and University Hospital Clementino Fraga Filho Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia R. 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