{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:31:57Z","timestamp":1790281917805,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,6]],"date-time":"2015-12-06T00:00:00Z","timestamp":1449360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007210","name":"RWTH Aachen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007210","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TRR57"],"award-info":[{"award-number":["SFB TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Iron constitutes a potentially toxic element and consequently, hepatic iron overload may accelerate liver disease progression and development of hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>). Hepcidin is the central negative regulator of iron metabolism that is produced primarily by the liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To study the prognostic significance of serum hepcidin, we assessed the influence of baseline serum hepcidin levels on the outcome of a French cohort encompassing 237 patients with alcoholic cirrhosis prospectively followed up in the setting of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hepcidin values correlated weakly with serum ferritin levels (<jats:italic>r<\/jats:italic> = 0.33) and hepatic iron scores (<jats:italic>r<\/jats:italic> = 0.3). After a median follow\u2010up of 68 months, patients with baseline lower hepcidin level had a higher risk of <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> occurrence [hazard ratio, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> = 1.76 (1.01\u20133.06), <jats:italic>P<\/jats:italic> = 0.031] and overall death [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> = 1.63 (1.07\u20132.44), <jats:italic>P<\/jats:italic> = 0.019]. According to Cox multivariate analyses, lower hepcidin levels were independently associated with death [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> = 2.84 (1.29\u20136.25), <jats:italic>P<\/jats:italic> = 0.009] along with higher Child\u2013Pugh score while <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> occurrence was mainly associated with clinical confounders interfering with iron metabolism (older age and higher <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, adjusted <jats:italic>P<\/jats:italic>\u2010value for hepcidin = 0.119).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, low\u2010serum hepcidin levels in patients with alcoholic cirrhosis bear a long\u2010term prognostic significance warranting further explorations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13007","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T09:19:12Z","timestamp":1447319952000},"page":"185-188","source":"Crossref","is-referenced-by-count":30,"title":["In alcoholic cirrhosis, low\u2010serum hepcidin levels associate with poor long\u2010term survival"],"prefix":"10.1111","volume":"36","author":[{"given":"Pierre","family":"Nahon","sequence":"first","affiliation":[{"name":"AP\u2010HP, Service d'H\u00e9patologie H\u00f4pital Jean Verdier Bondy France"},{"name":"Universit\u00e9 Paris 13, Sorbonne Paris Cit\u00e9 \u201cEquipe labellis\u00e9e Ligue Contre le Cancer\u201d F\u201093206 Saint\u2010Denis France"},{"name":"Inserm, UMR\u20101162 \u201cG\u00e9nomique fonctionnelle des tumeur solides\u201d F\u201075000 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwar","family":"Nuraldeen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III RWTH University Hospital Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Rufat","sequence":"additional","affiliation":[{"name":"APHP, Biostatistics Unit GH Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Sutton","sequence":"additional","affiliation":[{"name":"APHP, Biochemistry Unit Jean Verdier Hospital Bondy France"},{"name":"University Paris 13\u2010UFR SMBH\/INSERM U1148 Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Trautwein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III RWTH University Hospital Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Strnad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III RWTH University Hospital Aachen Aachen Germany"},{"name":"Interdisciplinary Center for Clinical Research (IZKF) RWTH University Hospital Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-427757"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.046"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.10.038"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27636"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-8-167"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.06.027"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-02-337907"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602098200"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00121.2010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1224577"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.11.045"}],"container-title":["Liver 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