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In these countries, <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> genotypes 1 and 2 cause large outbreaks and affect young subjects with a significant mortality rate in pregnant women and patients with cirrhosis. In the developed countries, <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> genotypes 3 and 4 are responsible for autochthonous, sporadic hepatitis and transmission is zoonotic. <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> can cause neurological disorders and in immunocompromised patients, chronic infections. The progression of acute hepatitis E is most often mild and resolves spontaneously. Diagnostic tools include anti\u2010<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgM antibodies in serum and\/or viral <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in the blood or stools by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Ribavirin is used to treat chronic infection. A vaccine has been developed in China.<\/jats:p>","DOI":"10.1111\/liv.13014","type":"journal-article","created":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T09:23:32Z","timestamp":1451899412000},"page":"130-134","source":"Crossref","is-referenced-by-count":36,"title":["Hepatitis E, the neglected one"],"prefix":"10.1111","volume":"36","author":[{"given":"H\u00e9l\u00e8ne","family":"Blasco\u2010Perrin","sequence":"first","affiliation":[{"name":"Service d'h\u00e9pato\u2010Gastro\u2010Ent\u00e9rologie H\u00f4pital Purpan CHU Toulouse Universit\u00e9 Paul Sabatier III Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Abravanel","sequence":"additional","affiliation":[{"name":"Laboratoire de Virologie H\u00f4pital Purpan CHU Toulouse Universit\u00e9 Paul Sabatier III Toulouse 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