{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:06Z","timestamp":1787015646582,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n The purpose of this study was to evaluate predictors of outcomes in combined liver\u2013kidney transplants for polycystic liver and kidney disease.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We queried the United Network for Organ Sharing dataset for combined liver\u2013kidney transplants performed from 1988 to 2013.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Out of 107 patients who had combined liver\u2013kidney transplants for polycystic liver and kidney disease, 84 were women (78.5%) with a mean age of 54.9 \u00b17.2 years. Kaplan\u2013Meier analysis demonstrated that patients undergoing liver\u2013kidney transplantation for polycystic liver and kidney disease had better survival than patients with polycystic liver disease undergoing liver transplant alone and those undergoing liver\u2013kidney transplantation for other indications. This group had a 1\u2010, 3\u2010 and 5\u2010year survival of 91%, 90% and 90%, respectively. Multivariable analysis demonstrated that an indication of polycystic liver and kidney disease for combined liver\u2013kidney transplant (hazard ratio, 0.29; 95% confidence interval, 0.129\u20130.526;\n P<\/jats:italic>\n < 0.001) and Model for End\u2010Stage Liver Disease score (hazard ratio, 1.271; 95% confidence interval, 1.093\u20131.477;\n P<\/jats:italic>\n = 0.002) are independently associated with patient survival. In a propensity score analysis adjusting for age, gender,\n cold ischaemia time<\/jats:styled-content>\n and total bilirubin and excluding hepatitis C, we found that patients transplanted with combined liver\u2013kidney for other indications have similar survival compared with our study group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Combined liver\u2013kidney transplantation for polycystic liver and kidney disease can achieve good outcomes in selected patients. On Cox regression analysis, patients with polycystic liver and kidney disease undergoing liver\u2013kidney transplantation had better survival compared with patients with combined liver\u2013kidney for other indications. After excluding hepatitis C patients, those transplanted for polycystic liver and kidney disease vs other indications had similar survival after combined liver\u2013kidney transplantation. Interestingly, patients in the combined polycystic liver and kidney disease group have significantly better outcomes than patients with polycystic liver disease undergoing liver transplant alone.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.13041","type":"journal-article","created":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T10:15:39Z","timestamp":1449915339000},"page":"1018-1025","source":"Crossref","is-referenced-by-count":30,"title":["Combined liver\u2013kidney transplantation for polycystic liver and kidney disease: analysis from the United Network for Organ Sharing dataset"],"prefix":"10.1111","volume":"36","author":[{"given":"Cristin","family":"Coquillard","sequence":"first","affiliation":[{"name":"Transplant Center University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Berger","sequence":"additional","affiliation":[{"name":"Transplant Center University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Daily","sequence":"additional","affiliation":[{"name":"Transplant Center University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malay","family":"Shah","sequence":"additional","affiliation":[{"name":"Transplant Center University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Mei","sequence":"additional","affiliation":[{"name":"Transplant Center University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Marti","sequence":"additional","affiliation":[{"name":"Transplant Center University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gedaly","sequence":"additional","affiliation":[{"name":"Transplant Center University of Kentucky College of Medicine Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022161"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199307293290508"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804458"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2012.00579.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/368295"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00080605"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.05.043"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840400404"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20780"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2001.22178"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20974"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2009.01.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198804000-00010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1990.01410170021003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02416.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000231712.75645.7a"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13041","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:53:32Z","timestamp":1695556412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,19]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/liv.13041"],"URL":"https:\/\/doi.org\/10.1111\/liv.13041","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,19]]}}}