{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:10:41Z","timestamp":1790241041989,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T00:00:00Z","timestamp":1454889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The hepatic venous pressure gradient (<jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content>) plays an important role in the diagnosis, prognosis and therapy of patients with cirrhosis and portal hypertension. One barrier to its widespread use is the potential for a low reproducibility. We aimed to evaluate the interobserver agreement in the interpretation of optimally acquired <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> tracings from patients with cirrhosis and different degrees of portal hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and fifteen tracings obtained from 51 patients with cirrhosis in a single centre were interpreted independently by two hepatologists: one experienced observer and one inexperienced observer. Correlation was performed by Pearson linear regression and the intraclass correlation coefficient (<jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content>). A Bland\u2013Altman plot was constructed to visualize how the differences between observers compared across the range of measurements. Logistic regression was used to identify predictors of \u226510% variation between observers' readings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant linear relationship between observers' readings <jats:italic>r<\/jats:italic> = 0.98 (<jats:italic>P<\/jats:italic> = 0.001). The <jats:styled-content style=\"fixed-case\">ICC<\/jats:styled-content> between observers (interobserver agreement) was also excellent at 0.991 (<jats:italic>P<\/jats:italic> = 0.001). Using the Bland\u2013Altman technique, the mean difference between the observers' readings was 0.2 mmHg (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: \u22121.2 mmHg to 1.6 mmHg). Thirteen per cent of all readings and 9% of readings with an <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> of \u226510 mmHg differed by \u226510%. As expected, a lower baseline <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> was a predictor of this variability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Interobserver reproducibility in the assessment of optimally acquired <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> tracings is excellent without differences related to experience. The data provide further support that the <jats:styled-content style=\"fixed-case\">HVPG<\/jats:styled-content> can be used accurately in clinical and research settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13065","type":"journal-article","created":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T03:33:30Z","timestamp":1452742410000},"page":"1160-1166","source":"Crossref","is-referenced-by-count":17,"title":["The interpretation of hepatic venous pressure gradient tracings \u2013 excellent interobserver agreement unrelated to experience"],"prefix":"10.1111","volume":"36","author":[{"given":"Puneeta","family":"Tandon","sequence":"first","affiliation":[{"name":"Section of Digestive Diseases Yale University School of Medicine New Haven CT USA"},{"name":"Cirrhosis Care Clinic University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ripoll","sequence":"additional","affiliation":[{"name":"Section of Digestive 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Garcia\u2010Tsao","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases Yale University School of Medicine New Haven CT 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