{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:51:04Z","timestamp":1770684664225,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,2,7]],"date-time":"2016-02-07T00:00:00Z","timestamp":1454803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Indocyanine green retention test (ICG\u2010r15) is a non\u2010invasive marker of functional hepatic reserve. Among patients with compensated cirrhosis, ICG\u2010r15 correlates to the degree of portal hypertension (PH); however, its prognostic relationship with the occurrence of decompensation events still requires clarification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ICG\u2010r15 was prospectively measured in 154 patients with compensated cirrhosis. Patients with hepatocellular carcinoma (HCC), Child\u2013Pugh B\u2010C, MELD&gt;15, bilirubin &gt; 2 mg\/dl, INR &gt; 1.5 or portal vein thrombosis were excluded. All patients underwent laboratory tests, upper endoscopy and hepatic venous pressure gradient (HVPG). Decompensation, development of HCC, liver transplant and death were recorded and analysed through competing\u2010risk analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study group was composed of 134 patients who were followed for a median of 39 months. During follow\u2010up, 46 patients (34.3%) developed liver decompensation. Hepatocellular carcinoma occurred in 18 patients and two patients died from non\u2010liver\u2010related causes. The 1\u2010, 2\u2010 and 3\u2010year cumulative incidences of decompensation were 9.7%, 28.4% and 33.4% respectively. Patients with ICG\u2010r15 &lt; 10% did not experience any decompensation events during follow\u2010up, while the 3\u2010year cumulative incidence of decompensation of patients with ICG\u2010r15 between 10% and 22.9% was 29.2% and that of patients with ICG\u2010r15 \u2265 23% was 70.0% (<jats:italic>P<\/jats:italic> &lt; 0.001). ICG\u2010r15 gave the lowest pseudo\u2010log\u2010likelihood value, in comparison to oesophageal varices present, MELD, low platelet count and HVPG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ICG\u2010r15 appears to be strictly related to liver decompensation, longitudinally confirming the preliminary findings of its correlation with PH among patients with compensated cirrhosis, and can be used for patient prognostication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13070","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T07:59:46Z","timestamp":1453276786000},"page":"1313-1321","source":"Crossref","is-referenced-by-count":37,"title":["Relationship between indocyanine green retention test, decompensation and survival in patients with Child\u2010Pugh A cirrhosis and portal hypertension"],"prefix":"10.1111","volume":"36","author":[{"given":"Andrea","family":"Lisotti","sequence":"first","affiliation":[{"name":"Department 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