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This explains the debate on whether surveillance for <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> should be continued in patients with documented cirrhosis regression following a <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> too. While regression of cirrhosis was documented to occur in a majority of patients with compensated cirrhosis 5\u00a0years after an <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> to interferon, it should be noted that this clinical benefit could be the consequence of treating a selected population with well\u2010compensated liver disease who in fact were interferon able. This may not be the case for most real\u2010life patients with advanced cirrhosis receiving direct antivirals, in whom liver fibrosis may have reached a point of no\u2010return thus potentially preventing the recovery of a normal liver architecture following <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>. Both invasive and non\u2010invasive tools have suboptimal diagnostic accuracy for fibrosis regression in non\u2010viraemic patients, and this prompts to follow international societies\u2019 recommendation to perform surveillance in patients with advanced liver fibrosis achieving a <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>, independently on liver histology outcome.<\/jats:p>","DOI":"10.1111\/liv.13106","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T07:26:15Z","timestamp":1456989975000},"page":"783-790","source":"Crossref","is-referenced-by-count":28,"title":["Should surveillance for liver cancer be modified in hepatitis C patients after treatment\u2010related cirrhosis regression?"],"prefix":"10.1111","volume":"36","author":[{"given":"Roberta","family":"D'Ambrosio","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico di Milano 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