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We explored relationships between non\u2010alcoholic fatty liver disease (NAFLD) and the hepatic expression of ABCA1\/ABCG1, as well as other target genes regulated by miR\u201033 (carnitine O\u2010octanoyltransferase, <jats:italic>CROT<\/jats:italic> and hydroxyacyl\u2010CoA\u2010dehydrogenase \u03b2\u2010subunit, <jats:italic>HADHB<\/jats:italic>) and miR\u2010144 (toll\u2010like receptor\u20102, <jats:italic>TLR2<\/jats:italic>). Moreover, we evaluated whether the expression of these genes is correlated with miR\u201033a\/b and miR\u2010144 expression in Mexican individuals with morbid obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010four morbidly obese subjects undergoing bariatric surgery were included in this study. Liver biopsies were obtained to measure hepatic triglyceride and free cholesterol contents, as well as ABCA1, ABCG1, CROT, HADHB, TLR2, miR\u201033a\/b and miR\u2010144 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hepatic free cholesterol content was significantly increased in NASH as compared to non\u2010NASH subjects, while ABCA1 and ABCG1 protein levels significantly decreased with NASH and fibrosis progression. The relative expression of miR\u201033a and miR\u2010144 correlated inversely with ABCA1 but not with ABCG1 protein levels. Moreover, both miRNAs increased significantly in NASH individuals. miR\u201033 target genes <jats:italic>CROT<\/jats:italic> and <jats:italic>HADHB<\/jats:italic> correlated inversely with miR\u201033a. However, the expression of these genes was not associated with NASH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>miR\u201033a\/144 and their target gene <jats:italic>ABCA1<\/jats:italic> may contribute to the pathogenesis of NASH in morbidly obese subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13109","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T07:53:07Z","timestamp":1457250787000},"page":"1383-1391","source":"Crossref","is-referenced-by-count":71,"title":["Hepatic miR\u201033a\/miR\u2010144 and their target gene <i>ABCA1<\/i> are associated with steatohepatitis in morbidly obese subjects"],"prefix":"10.1111","volume":"36","author":[{"given":"Joel","family":"Vega\u2010Badillo","sequence":"first","affiliation":[{"name":"Programa de Doctorado en Ciencias Bioqu\u00edmicas Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"},{"name":"Unidad de Gen\u00f3mica de Poblaciones Aplicada a la Salud Facultad de Qu\u00edmica UNAM\/Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Guti\u00e9rrez\u2010Vidal","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Ciencias Bioqu\u00edmicas Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) Mexico City Mexico"},{"name":"Unidad de Gen\u00f3mica de Poblaciones Aplicada a la Salud Facultad de Qu\u00edmica UNAM\/Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Hern\u00e1ndez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Unidad de Gen\u00f3mica de Poblaciones Aplicada a la Salud Facultad de Qu\u00edmica UNAM\/Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN) Mexico City 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Inmunolog\u00eda Instituto Nacional de Cardiolog\u00eda \u201cIgnacio Ch\u00e1vez\u201d (INCICh) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Mor\u00e1n\u2010Ramos","sequence":"additional","affiliation":[{"name":"Unidad de Gen\u00f3mica de Poblaciones Aplicada a la Salud Facultad de Qu\u00edmica UNAM\/Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Larrieta\u2010Carrasco","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterolog\u00eda Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n (INCMNSZ) Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzel","family":"Fern\u00e1ndez\u2010Silva","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Integral de Cirug\u00eda para la Obesidad y Enfermedades Metab\u00f3licas Hospital 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