{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:37Z","timestamp":1787015737996,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Olympus-Core National Endoscopy Research","award":["RB4803"],"award-info":[{"award-number":["RB4803"]}]},{"name":"Intromedic Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n \n Screening for oesophageal varices (\n OV<\/jats:styled-content>\n ) using conventional oesophagogastroduodenoscopy (C\u2010\n OGD<\/jats:styled-content>\n ) is invasive and requires costly monitoring, recovery, and decontamination facilities. We aimed to evaluate the technical feasibility, acceptability and accuracy of a novel, portable and disposable office\u2010based transnasal endoscope (\n EG<\/jats:styled-content>\n Scan\n \u2122<\/jats:sup>\n ) compared to C\u2010\n OGD<\/jats:styled-content>\n as the reference standard.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a prospective cohort study. Consecutive adult patients with cirrhosis were invited to participate. All subjects underwent the two procedures on the same day performed by two endoscopists in a blinded design. Patients completed preference and validated tolerability (10\u2010point visual analogue scale (\n VAS<\/jats:styled-content>\n )) questionnaires on day 0 and day 14 post procedures.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Forty\u2010five of 50 patients (90%) completed both interventions. Mean age was 59 years and\n OV<\/jats:styled-content>\n prevalence was 49%.\n <\/jats:p>\n \n Patients reported higher preference (percentage) and better experience (mean\n VAS<\/jats:styled-content>\n ) with\n EG<\/jats:styled-content>\n Scan compared to C\u2010\n OGD<\/jats:styled-content>\n on day 0 (76.5% vs. 23.5%,\n P<\/jats:italic>\n < 0.001; 7.8 vs. 6.8,\n P<\/jats:italic>\n = 0.058, respectively) and day 14 (77.8% vs. 22.2%,\n P<\/jats:italic>\n < 0.001; 7.0 vs. 5.5,\n P<\/jats:italic>\n = 0.0013 respectively). Sensitivity and specificity of the\n EG<\/jats:styled-content>\n Scan for the diagnosis of any size\n OV<\/jats:styled-content>\n were 0.82 (95% confidence interval (\n CI<\/jats:styled-content>\n ) 0.60\u20130.95), and 0.78 (95%\n CI<\/jats:styled-content>\n 0.56\u20130.93) respectively. Corresponding values for the diagnosis of clinically significant (medium\/large)\n OV<\/jats:styled-content>\n were 0.92 (95%\n CI<\/jats:styled-content>\n 0.62\u20131.0), 0.97 (95%\n CI<\/jats:styled-content>\n 0.84\u20131.0) respectively. No serious adverse events occurred.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n EG<\/jats:styled-content>\n Scan accuracy was higher for the diagnosis of medium\/large\n OV<\/jats:styled-content>\n compared to any size\n OV<\/jats:styled-content>\n . Patients' preference and overall experience of the\n EG<\/jats:styled-content>\n Scan was favourable compared to C\u2010\n OGD<\/jats:styled-content>\n 14 days after procedures.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.13152","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T05:20:13Z","timestamp":1461993613000},"page":"1639-1648","source":"Crossref","is-referenced-by-count":12,"title":["The detection of oesophageal varices using a novel, disposable, probe\u2010based transnasal endoscope: a prospective diagnostic pilot study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-1246","authenticated-orcid":false,"given":"Sarmed S.","family":"Sami","sequence":"first","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krish","family":"Ragunath","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie A.","family":"Wilkes","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"James","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Mansilla\u2010Vivar","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"Ortiz\u2010Fern\u00e1ndez\u2010Sordo","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"White","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amardeep","family":"Khanna","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Coletta","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Department of Pathophysiology and Transplantation Universit\u00e0 degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Samuel","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guruprasad P.","family":"Aithal","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indra Neil","family":"Guha","sequence":"additional","affiliation":[{"name":"NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust and University of Nottingham Nottingham 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