{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:28:42Z","timestamp":1790252922106,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>No published study to date has provided a careful analysis of the effects of a sustained viral response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) on the outcomes of patients with compensated hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>)\u2010related cirrhosis in relation to the degree of portal hypertension. Therefore, we estimated the impact of achieving <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> on disease progression, hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>) development and mortality in a large cohort of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> patients with cirrhosis with or without oesophageal varices (<jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>s) at the start of antiviral therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 535 Caucasian patients were prospectively recruited to this study. All patients had a clinical or histological diagnosis of compensated <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related cirrhosis and underwent interferon\u2010based therapy. Competing risks and a multistate model were analysed according to the presence or absence of <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>s at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to patients without <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>, a greater proportion of patients who achieved <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> showed no liver disease progression after 10 years (36.3% vs. 61.3% of patients without baseline <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>s; 29.6% vs. 64.3% of patients with baseline <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>s). Achievement of <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> was significantly associated with reduced occurrence rates of de\u2010novo <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>s, hepatic decompensation and <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>. Compared to patients without <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>, patients with <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> had lower likelihoods of liver\u2010related death at 10 years (20.6% vs. 10.3% of patients without baseline <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>s; 50.5% vs. 21.8% of patients with baseline <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with compensated <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010related cirrhosis with or without <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>s at baseline, <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> is associated with reduced disease progression and liver\u2010related mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13156","type":"journal-article","created":{"date-parts":[[2016,5,10]],"date-time":"2016-05-10T15:27:05Z","timestamp":1462894025000},"page":"1765-1773","source":"Crossref","is-referenced-by-count":18,"title":["Impact of virus eradication in patients with compensated hepatitis <scp>C<\/scp> virus\u2010related cirrhosis: competing risks and multistate model"],"prefix":"10.1111","volume":"36","author":[{"given":"Salvatore","family":"Petta","sequence":"first","affiliation":[{"name":"Sezione di GAstroenterologia e Epatologia, Di.Bi.M.I.S. University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Sezione di GAstroenterologia e Epatologia, Di.Bi.M.I.S. University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savino","family":"Bruno","sequence":"additional","affiliation":[{"name":"Humanitas University and Humanitas Research Hospital Rozzano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Enea","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche Istituto per l'Ambiente Marino Costiero Mazara del Vallo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Calvaruso","sequence":"additional","affiliation":[{"name":"Sezione di GAstroenterologia e Epatologia, Di.Bi.M.I.S. 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