{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:42:50Z","timestamp":1790674970246,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,6,30]],"date-time":"2016-06-30T00:00:00Z","timestamp":1467244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>In 2015, a national Egyptian health issue survey was conducted to describe the prevalence of hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection. In this paper, we describe the <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> burden in 2015, compare the results with the national survey conducted in 2008, and discuss the implications of the new findings on prevention of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> in Egypt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multistage probability sampling approach was used, similar to the national demographic survey conducted in 2008. More than 90% of sampled individuals complied with the interview and provided blood samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 15\u201359\u2010year age groups, the prevalence of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibody was found to be 10.0% (95% CI 9.5\u201310.5) and that of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> RNA to be 7.0% (95% CI 6.6\u20137.4). In children, 1\u201314 years old, the prevalence of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibody and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> RNA were 0.4% (95% CI 0.3\u20130.5) and 0.2% (95% CI 0.1\u20130.3) respectively. Approximately, 3.7 million persons have chronic <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> infection in the age group 15\u201359 in 2015. An estimated 29% reduction in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> RNA prevalence has been seen since 2008, which is largely attributable to the ageing of the group infected 40\u201350 years ago during the mass schistosomiasis treatment campaigns. Prevention efforts may have also contributed to this decline, with an estimated 75% (95% CI 6\u201345) decrease in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> incidence in the 0\u201319 year age groups over the past 20 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings can be used to shape future <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> prevention policies in Egypt.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13186","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T16:15:12Z","timestamp":1465402512000},"page":"45-53","source":"Crossref","is-referenced-by-count":188,"title":["The prevalence of hepatitis C virus infection in Egypt 2015: implications for future policy on prevention and treatment"],"prefix":"10.1111","volume":"37","author":[{"given":"Amr","family":"Kandeel","sequence":"first","affiliation":[{"name":"Ministry of Health and Population Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Genedy","sequence":"additional","affiliation":[{"name":"Ministry of Health and Population Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"El\u2010Refai","sequence":"additional","affiliation":[{"name":"Ministry of Health and Population Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Funk","sequence":"additional","affiliation":[{"name":"Institut Pasteur Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Fontanet","sequence":"additional","affiliation":[{"name":"Institut Pasteur Paris France"},{"name":"Conservatoire National des Arts et M\u00e9tiers Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Talaat","sequence":"additional","affiliation":[{"name":"Global Disease Detection Regional Center US Centers for Disease Control and Prevention Cairo Egypt"},{"name":"US Naval Medical Research Unit, No.3 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.027"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26141"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.05.013"},{"key":"e_1_2_8_5_1","volume-title":"Egypt Demographic and Health Survey 2008","author":"El\u2010Zanaty F","year":"2009"},{"key":"e_1_2_8_6_1","unstructured":"Ministry of Health Egypt El\u2010Zanaty and Associates Egypt and ICF International. 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