{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:48:41Z","timestamp":1789879721350,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T00:00:00Z","timestamp":1474588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004100","name":"Labex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n Efficacy of radioembolization is derived from radioinduced damage, whereas tumour dosimetry is not considered as yet in prospective clinical trials.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n This study evaluates the impact of tumour dose (\n TD<\/jats:styled-content>\n ), based on\n 99m<\/jats:sup>\n Tc macroaggregated albumin (\n MAA<\/jats:styled-content>\n ) quantification, on response and overall survival (\n OS<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n We consecutively included 85 patients with hepatocellular carcinoma treated with\n 90<\/jats:sup>\n Y\u2010loaded glass microspheres.\n TD<\/jats:styled-content>\n was calculated using a quantitative analysis of the\n MAA SPECT<\/jats:styled-content>\n \/\n CT<\/jats:styled-content>\n . Responses were assessed after 3\u00a0months using the European Association for the Study of the Liver criteria.\n OS<\/jats:styled-content>\n was assessed using Kaplan\u2013Meier tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Response rate was 80.3% on lesion\u2010based analysis (n=132), and 77.5% on patient\u2010based analysis. The response rate was only 9.1% for patients with\n TD<\/jats:styled-content>\n <205\u00a0Gy against 89.7% for those with\n TD<\/jats:styled-content>\n \u2265205\u00a0Gy (\n P<\/jats:italic>\n <10\n \u22127<\/jats:sup>\n ). Non\u2010portal vein thrombosis (\n PVT<\/jats:styled-content>\n ) patients exhibited a median\n OS<\/jats:styled-content>\n of 11.75\u00a0m (95%\n CI<\/jats:styled-content>\n : 3\u201330.7\u00a0m) for\n TD<\/jats:styled-content>\n \u00a0<205\u00a0Gy, and 25\u00a0m (95%\n CI<\/jats:styled-content>\n : 15\u201334.7\u00a0m) for\n TD<\/jats:styled-content>\n \u2265205\u00a0Gy (\n P<\/jats:italic>\n =.0391).\n PVT<\/jats:styled-content>\n patients exhibited a 4.35\u00a0m median\n OS<\/jats:styled-content>\n (95%\n CI<\/jats:styled-content>\n : 2\u20138\u00a0m) for\n TD<\/jats:styled-content>\n <205\u00a0Gy, and 15.7\u00a0m (95%\n CI<\/jats:styled-content>\n : 9.5\u201325.5\u00a0m) for\n TD<\/jats:styled-content>\n \u2265205\u00a0Gy, (\n P<\/jats:italic>\n =.0004), with\n HR<\/jats:styled-content>\n of 6.99.\n PVT<\/jats:styled-content>\n patients exhibited a median\n OS<\/jats:styled-content>\n of 3.6\u00a0m (95%\n CI<\/jats:styled-content>\n : 2\u20138\u00a0m) when\n PVT MAA<\/jats:styled-content>\n targeting was poor or with\n TD<\/jats:styled-content>\n <205\u00a0Gy (poor candidate), vs 17.5\u00a0m (95%\n CI<\/jats:styled-content>\n : 11\u201326.5\u00a0m) for the others identified as good candidates (\n P<\/jats:italic>\n <.0001), with\n HR<\/jats:styled-content>\n of 12.85.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study confirms the highly predictive value of\n MAA<\/jats:styled-content>\n \u2010based\n TD<\/jats:styled-content>\n evaluation for response and\n OS<\/jats:styled-content>\n .\n TD<\/jats:styled-content>\n evaluation and\n PVT MAA<\/jats:styled-content>\n targeting should be further evaluated in ongoing trials, whereas personalized dosimetry should be implemented in new trial designs.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.13220","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T09:03:04Z","timestamp":1470906184000},"page":"101-110","source":"Crossref","is-referenced-by-count":91,"title":["High impact of macroaggregated albumin\u2010based tumour dose on response and overall survival in hepatocellular carcinoma patients treated with\n 90<\/sup>\n Y\u2010loaded glass microsphere radioembolization"],"prefix":"10.1111","volume":"37","author":[{"given":"Etienne","family":"Garin","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine Cancer Institute Eug\u00e8ne Marquis Rennes France"},{"name":"University of Rennes 1 Rennes France"},{"name":"Liver Metabolisms and Cancer INSERM, U\u2010991 Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Rolland","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Cancer Institute Eug\u00e8ne Marquis Rennes 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