{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:28:07Z","timestamp":1778761687548,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background &amp; Aims<\/jats:title><jats:p>Clinical course and risk factors of death in non\u2010spontaneous bacterial peritonitis (<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>) infections are poorly known. We assessed the prevalence of acute kidney injury (<jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>) and type\u20101 hepatorenal syndrome (<jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content>), hospital, 30\u2010day and 90\u2010day mortality and risk factors of death in 441 decompensated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analysis of 615 non\u2010<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> infections (161 urinary infections (<jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content>), 95 cellulitis, 92 suspected infections, 92 bacteraemias, 84 pneumonias, 21 bronchitis, 18 cholangitis, 15 spontaneous empyema, 13 secondary peritonitis, 24 other).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010six percent of infections solved. <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> and type\u20101 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> were developed in 37% and 9% of infections respectively. Overall hospital, 30\u2010day and 90\u2010day mortality rates were 11%, 12% and 18% respectively. Clinical course and mortality differed markedly across infections. Endocarditis, osteoarticular infections, pneumonia, spontaneous bacteraemia, cholangitis, secondary peritonitis and <jats:styled-content style=\"fixed-case\">UTI<\/jats:styled-content> showed higher rates of <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>. Prevalence of type\u20101 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> was not significantly different among infections. Endocarditis, secondary peritonitis, pneumonia and bacteraemia showed lower rates of renal impairment resolution and higher hospital mortality associated with <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content> (42% vs 12%, <jats:italic>P<\/jats:italic>&lt;.0001) or type\u20101 <jats:styled-content style=\"fixed-case\">HRS<\/jats:styled-content> (71% vs 27%, <jats:italic>P<\/jats:italic>=.003) than the rest of infections. Age (HR: 1.04), serum sodium (HR: 0.91), serum bilirubin (HR: 1.06), <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> (HR: 1.91), hepatic encephalopathy (HR: 2.44), ascites (HR: 3.06) and multidrug\u2010resistant isolation (HR: 2.27) at infection diagnosis were independent predictors of death during hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010<jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content> infections constitute a heterogeneous group regarding clinical course and prognosis. Endocarditis, secondary peritonitis, pneumonia and bacteraemia show worse prognosis. The combination of data of liver and renal dysfunction and of the type of infection allows the identification of patients with poor prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13239","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T08:03:11Z","timestamp":1472112191000},"page":"385-395","source":"Crossref","is-referenced-by-count":44,"title":["Clinical course and short\u2010term mortality of cirrhotic patients with infections other than spontaneous bacterial peritonitis"],"prefix":"10.1111","volume":"37","author":[{"given":"Javier","family":"Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Liver Unit Hospital Clinic  Barcelona Spain"},{"name":"IDIBAPS University of Barcelona  Barcelona Spain"},{"name":"CIBEREHED  Barcelona Spain"},{"name":"EASL\u2010CLIF Consortium\u2010Efclif  Barcelona 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