{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:11:49Z","timestamp":1791364309983,"version":"4.3.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T00:00:00Z","timestamp":1474761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB TRR57"],"award-info":[{"award-number":["SFB TRR57"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["668031"],"award-info":[{"award-number":["668031"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Abstract<\/jats:title>Background & Aims<\/jats:title>Clinically significant portal hypertension (CSPH<\/jats:styled-content>) is associated with severe complications and decompensation of cirrhosis. Liver stiffness measured either by transient elastography (TE<\/jats:styled-content>) or Shear\u2010wave elastography (SWE<\/jats:styled-content>) and spleen stiffness by TE<\/jats:styled-content> might be helpful in the diagnosis of CSPH<\/jats:styled-content>. We recently showed the algorithm to rule\u2010out CSPH<\/jats:styled-content> using sequential liver\u2010 (L\u2010SWE<\/jats:styled-content>) and spleen\u2010Shear\u2010wave elastography (S\u2010SWE<\/jats:styled-content>). This study investigated the diagnostic value of S\u2010SWE<\/jats:styled-content> for diagnosis of CSPH<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred and fifty\u2010eight cirrhotic patients with pressure gradient measurements were included into this prospective multicentre study. L\u2010SWE<\/jats:styled-content> was measured in 155 patients, S\u2010SWE<\/jats:styled-content> in 112 patients, and both in 109 patients.<\/jats:p><\/jats:sec>Results<\/jats:title>Liver\u2010shear\u2010wave elastography and S\u2010SWE<\/jats:styled-content> correlated with clinical events and decompensation. SWE<\/jats:styled-content> of liver and spleen revealed strong correlations with the pressure gradient and to differentiate between patients with and without CSPH<\/jats:styled-content>. The best cut\u2010off values were 24.6\u00a0kPa:L\u2010SWE<\/jats:styled-content> and 26.3\u00a0kPa:S\u2010SWE<\/jats:styled-content>. L\u2010SWE<\/jats:styled-content> \u226416.0\u00a0kPa and S\u2010SWE<\/jats:styled-content> \u226421.7\u00a0kPa were able to rule\u2010out CSPH<\/jats:styled-content>. Cut\u2010off values of L\u2010SWE<\/jats:styled-content> >29.5\u00a0kPa and S\u2010SWE<\/jats:styled-content> >35.6\u00a0kPa were able to rule\u2010in CSPH<\/jats:styled-content> (specificity >92%). Patients with a L\u2010SWE<\/jats:styled-content> >38.0\u00a0kPa had likely CSPH<\/jats:styled-content>. In patients with L\u2010SWE<\/jats:styled-content> \u226438.0\u00a0kPa, a S\u2010SWE<\/jats:styled-content> >27.9\u00a0kPa ruled in CSPH<\/jats:styled-content>. This algorithm has a sensitivity of 89.2% and a specificity of 91.4% to rule\u2010in CSPH<\/jats:styled-content>. Patients not fulfilling these criteria may undergo HVPG<\/jats:styled-content> measurement.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Liver and spleen SWE<\/jats:styled-content> correlate with portal pressure and can both be used as a non\u2010invasive method to investigate CSPH<\/jats:styled-content>. Even though external validation is still missing, these algorithms to rule\u2010out and rule\u2010in CSPH<\/jats:styled-content> using sequential SWE<\/jats:styled-content> of liver and spleen might change the clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/liv.13243","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T07:53:38Z","timestamp":1472457218000},"page":"396-405","source":"Crossref","is-referenced-by-count":136,"title":["Shear\u2010wave elastography of the liver and spleen identifies clinically significant portal hypertension: A prospective multicentre study"],"prefix":"10.1111","volume":"37","author":[{"given":"Christian","family":"Jansen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bogs","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University 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