{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T14:59:39Z","timestamp":1761663579739},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Alcoholic liver disease, considered as a self\u2010inflected disease, is an example of how moral judgment may affect ethical exercise of medicine which requires equity and fair utilization of a scarce resource in a context of organ shortage. Some consider that selection process should prioritize access to liver transplantation (LT) for patients who develop liver failure \u201cthrough no fault of their own\u201d even if limiting care because of a patient's perceived responsibility has been considered unethical. The absence of improvement after alcohol withdrawal, the high short\u2010term mortality risk and the poor predictability of the 6\u2010month rule in post\u2010LT relapse in alcohol consumption in AH patients not responding to medical therapy led to recommend an evaluation of LT. In the French\u2010Belgian pilot study, 26 patients with severe AH not responding to medical therapy underwent early LT (eLT). Stringent selection criteria were applied. Six\u2010month and 2\u2010year survivals of eLT patients were better than that of non\u2010transplanted matched controls: 77% vs 23% and 71% vs 23% respectively. Alcohol relapse occurred in 12% of patients after eLT. Three studies confirmed these results. The impact organ donation should be limited as showed by a recent survey and the efforts that should be made in public information campaigns based on scientific data and medical ethics. In conclusion, the ongoing accumulation of scientific evidence and requirement of ethical exercise of medicine lead to continue evaluating eLT as a therapeutic option in patients with severe AH not responding to medical therapy.<\/jats:p>","DOI":"10.1111\/liv.13248","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T14:26:19Z","timestamp":1488205579000},"page":"337-339","source":"Crossref","is-referenced-by-count":28,"title":["Liver transplantation for patients with alcoholic hepatitis"],"prefix":"10.1111","volume":"37","author":[{"given":"Florent","family":"Artru","sequence":"first","affiliation":[{"name":"Hepatology CHRU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Louvet","sequence":"additional","affiliation":[{"name":"Hepatology CHRU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Mathurin","sequence":"additional","affiliation":[{"name":"Hepatology CHRU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.11.015"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1684\/hpg.2013.0975"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.521"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00006"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.12.021"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105703"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.044"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.204"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00047-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.21298"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25544"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20765"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13586"},{"key":"e_1_2_5_15_1","article-title":"Three\u2010year results of a pilot program in early liver transplantation for severe alcoholic hepatitis","author":"Lee BP","year":"2016","journal-title":"Ann Surg"},{"key":"e_1_2_5_16_1","unstructured":"HanounehIH HumbersonA FioritaAL et\u00a0al.Ohio Solid Organ Transplantation Consortium (OSOTC) Exception Criteria for Early Liver Transplantation (LT) in Severe Alcoholic Hepatitis. Abs 121 AASLD The liver meeting Boston2014."},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24208"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13176"}],"container-title":["Liver International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fliv.13248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/liv.13248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:56:48Z","timestamp":1695495408000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/liv.13248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,27]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/liv.13248"],"URL":"https:\/\/doi.org\/10.1111\/liv.13248","archive":["Portico"],"relation":{},"ISSN":["1478-3223","1478-3231"],"issn-type":[{"value":"1478-3223","type":"print"},{"value":"1478-3231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,27]]}}}