{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:58Z","timestamp":1787015638015,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T00:00:00Z","timestamp":1475539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001009","name":"Bristol-Myers Squibb Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI\u2010EX103\u201010319PC"],"award-info":[{"award-number":["NHRI\u2010EX103\u201010319PC"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Liver International"],"published-print":{"date-parts":[[2016,12]]},"abstract":"Abstract<\/jats:title>\n \n Background & Aims<\/jats:title>\n \n Oral antiviral therapy may reduce the disease progression of chronic hepatitis B (\n CHB<\/jats:styled-content>\n ) patients. We aimed to further investigate the efficacy of long\u2010term entecavir therapy in reduction of the risk of hepatocellular carcinoma (\n HCC<\/jats:styled-content>\n ), cirrhotic events and mortality in a large group of\n CHB<\/jats:styled-content>\n \u2010related cirrhosis patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The C\u2010\n TEAM<\/jats:styled-content>\n (Cirrhosis\u2010Taiwanese EntecAvir Multicenter) study was a nationwide, multicenter, retrospective\u2013prospective cohort study in Taiwan. We enrolled treatment\u2010na\u00efve patients with\n CHB<\/jats:styled-content>\n \u2010related cirrhosis and baseline\n HBV<\/jats:styled-content>\n \u2010\n DNA<\/jats:styled-content>\n \u22652000\u00a0IU\/mL receiving long\u2010term entecavir therapy and compared the development of\n HCC<\/jats:styled-content>\n , cirrhotic events and mortality with that of a historical untreated cohort.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 1315 entecavir\u2010treated and 503 untreated patients with cirrhosis were enrolled, with median treatment and follow\u2010up durations of 4 and 6\u00a0years respectively. Compared with the untreated cohort, entecavir therapy was associated with a 60%\n HCC<\/jats:styled-content>\n risk reduction [hazard ratio (\n HR<\/jats:styled-content>\n ): 0.40, 95% confidence interval (\n CI<\/jats:styled-content>\n ): 0.28\u20100.57]. Additionally, an older age, the male gender,\n HBeA<\/jats:styled-content>\n g positivity, alpha\u2010fetoprotein (\n AFP<\/jats:styled-content>\n )\u22657\u00a0ng\/mL before therapy were independent predictors of\n HCC<\/jats:styled-content>\n development. Further analysis showed that entecavir therapy significantly reduced risks of variceal bleeding, spontaneous bacterial peritonitis, and liver\u2010related and all\u2010cause mortality. These findings were confirmed by propensity score\u2010matched cohorts in sensitivity analysis. In patients under entecavir therapy, an older age, the male gender,\n HBeA<\/jats:styled-content>\n g positivity,\n AFP<\/jats:styled-content>\n level \u22657\u00a0ng\/mL before therapy, and 1\u2010year virological response were predictive of\n HCC<\/jats:styled-content>\n development.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Four\u2010year entecavir therapy significantly reduces the risk of\n HCC<\/jats:styled-content>\n , cirrhotic events and mortality in patients with\n CHB<\/jats:styled-content>\n \u2010related cirrhosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/liv.13253","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T05:29:49Z","timestamp":1474003789000},"page":"1755-1764","source":"Crossref","is-referenced-by-count":196,"title":["Four\u2010year entecavir therapy reduces hepatocellular carcinoma, cirrhotic events and mortality in chronic hepatitis B patients"],"prefix":"10.1111","volume":"36","author":[{"given":"Tung\u2010Hung","family":"Su","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Hui","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chia\u2010Yi Christian Hospital Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Long","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Che","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Chung Shan Medical University Hospital Taichung 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Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Shun","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Gastroenterology Department of Internal Medicine and Department of Medical Research Tungs\u2019 Taichung MetroHarbor Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lein\u2010Ray","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tainan Municipal Hospital Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Jer","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University 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